Herbicidal substituted pyrazoles

ABSTRACT

The present invention relates to certain novel substituted 3-phenoxypyrazoles and their use as herbicides.

RELATED APPLICATIONS

This application is a continuation-in-part of application Ser. No. 07/277,087, filed 11/23/88 now abandoned.

FIELD OF THE INVENTION

The present invention relates to certain novel substituted 3-phenoxypyrazoles and their use as herbicides.

BACKGROUND OF THE INVENTION

Uncontrolled weed growth continues to be a problem in our environment. In growing crops, uncontrolled weed growth normally results in lower crop yield and reduced crop quality. Herbicides have been developed to control weed growth. However, many herbicides injure adjacent useful plants at efficacious application rates. Further, many non-selective herbicides have environmental problems.

Plath et al U.S. Pat. No. 4,298,749 discloses certain substituted pyrazole ether derivatives including pyrazole phenyl ethers as having herbicidal activity. However, there still is a need in the art for herbicides which have the advantages of being safe on crops and efficacious at low application rates for cost savings and lower pesticide use.

SUMMARY OF THE INVENTION

The present invention relates to a novel class of substituted 3-phenoxypyrazoles, herbicidal compositions thereof, their use as herbicides and precursors for the novel class of 3-phenoxypyrazoles. Applicants have discovered that certain 3-phenoxypyrazole herbicides having a substitution pattern have herbicidal activity and that many of them have exceptionally high herbicidal activity. The unique substitution pattern includes importantly a para-nitro substituent on the phenyl ring. The unique substitution pattern also provides for specific substituents in the 1-, 4- and 5-positions of the pyrazole ring. The phenyl ring also has in one meta position a substituent which is (i) a hydrido radical or, preferably (ii) a substituent other than hydrido having a molecular weight up to about 300. It has been found that it is the unique combination of the para-nitro substituent on the phenyl ring and substituents in the 1-, 4- and 5-positions of the pyrazole ring which provide the class of compounds with herbicidal activity and that the nature of the meta substituent (if any) on the phenyl ring is not critical for the presence of herbicidal activity.

The class of unique compounds is defined as 3-phenoxypyrazoles and agronimically acceptable salts there of wherein (a) the pyrazole ringhas a methyl, ethyl, halomethyl or haloethyl substituent in the 1-position; a methyl or ethyl substituent in the 4-position and a chloro, cyano, halomethyl, haloethyl, metylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl ethylsulfonyl or methoxymethyl substituent in the 5-position and (b) the phenyl ring also has a para nitro substituent and a meta substituent having a molecular weight of up to about 300 and consisting of one or more atoms selected from the group consisting of H, C, Cl, F, Br, I, N, S, O, Si and P. The meta substituent is preferably an organic radical having up to about 10 and preferably up to about 8 carbon atoms; preferably having a molecular weight of up to about 300, preferably up to about 250, more preferably up to about 200 and having one or more atoms selected from the group consisting of H, C, Cl, F, Br, I, N, S, O, Si and P. More preferably the organic radical has one or more atoms selected from the group consisting of H, C, Cl, F, Br, N, S and 0. Preferably the pyrazole ring has a halo substituent in the 4-position, preferably Cl or Br. Preferably the pyrazole ring has a halomethyl, haloethyl, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl substituent in the 5-position, more preferably a halomethyl or methylsulfonyl substituent in the 5-position.

The meta organic radical normally will comprise a saturated or unsaturated carbon chain having up to about 10 (preferably up to about 8) carbon atoms which may be linear, branched or cyclic and optionally substituted by a variety of substituents such as halo, nitro, cyano, hydroxy, and the like. The radical has a molecular weight of up to about 300 and preferably up to about 250 (most preferably up to about 200). The carbon chain may be bonded directly to the phenyl ring or through one or more difunctional substituents selected from (i) substituents comprising (or consisting of) one or more heteroatoms selected from the group consisting of N, S, O and P (preferably O and N) and (ii) substituents comprising one or more atoms selected from C and S which are bonded to one or more of said heteroatoms (preferably carbonyl). The carbon chain is optionally interrupted or terminated with one or more substituents selected from (i) substituents comprising one or more heteroatoms selected from the group consisting of N, S, O and P (preferably O, N and S) and (ii) substituents comprising one or more atoms selected from C and S which are bonded to one or more of said heteroatoms (preferably carbonyl or sulfonyl). The heteroatom may optionally be substituted with substituents such as alkyl, alkoxy or the like. The carbon chain may also be optionally substituted with (i) aryl, preferably phenyl or phenylalkyl optionally substituted with substituents such as halo, nitro, cyano, alkoxy, haloalkyl, amino, hydroxy or the like or (ii) a 3 to 7 membered, saturated or unsaturated heterocyclic radical having 1 to 3 heteroatoms selected from the group consisting of N, O and S.

The utility of the compounds of this invention as an active ingredient in herbicidal compositions formulated therewith and the method of use thereof will be described below.

DETAILED DESCRIPTION OF THE INVENTION

A preferred embodiment of the unique class of the 3-phenoxypyrazoles of the present invention are compounds represented by the Formula I and agronomically acceptable salts thereof: ##STR1## wherein:

R₁ is methyl, ethyl, halomethyl or haloethyl;

R₂ is chloro, cyano, halomethyl, haloethyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl or methoxymethyl

R₃ is methyl or ethyl; and

Z is ##STR2## wherein: R_(a) is selected from hydrido, hydroxy, halo, cyano, alkyl, alkenyl, alkynyl, unsubstituted or substituted with one or more hydroxy, halo, cyano, alkoxy, amino, alkylamino, alkylthio, phenyl, hydroxycarbonyl, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, alkylcarbonyloxy, di(alkoxy)carbonyl, di(alkoxycarbonyl), alkoxyalkylaminocarbonyl, alkylsulfinyl, alkylsulfonyl, alkoxycarbonylalkylsulfonyl, phosphonyl and alkylphosphinyl.

R_(b) is selected from hydroxy, hydrido, halo, alkyl, alkoxy, alkenyloxy, alkynyloxy, phenoxy, benzyloxy, hydrazino, alkylhydrazino, oximino, phenylamino, phenylthio, alkylthio, amino, alkylamino, alkenylamino, alkynylamino, di-, tri- or tetra(alkoxy), di(alkylamino), alkylaminoalkoxy, alkoxyalkylamino, hydroxycarbonyl, alkylaminooxy, alkoxyamino, alkylthioalkoxy, alkylthioalkyl, alkoxyalkyl, alkylsufonylalkoxy, alkylsufinylalkyloxy, alkylsulfonylamino, alkylsulfonylalkylamino, hydroxycarbonylalkylamino, alkoxycarbonylalkyl, alkylcarbonylalkoxy, alkoxycarbonylalkenyloxy, alkoxycarbonylalkoxy, alkoxycarbonylalkylthio, alkylcarbonylamino, aminocarbonylalkylamino, di(alkoxycarbonyl)alkoxy, alkylaminocarbonylalkoxy, hydroxycarbonylalkylamino, alkoxycarbonylalkylamino, alkylcarbonyloxyalkoxy; alkylcarbonyloxydi(alkoxy); alkylcarbonyloxyalkylamino, alkoxycarbonyloxyalkoxy; alkoxyalylcarbonyloxyalkoxy; alkoxycarbonylaminoalkoxy, alkoxycarbonylalkoxyamino, alkoxycarbonylalkylcarbonyloxyalkoxy alkenylaminothiocarbonylamino, alkoxycarbonyloximino, alkoxyoximino, alkylcarbonyloximino, and alkylphosphonylalkoxy;

R_(c) is hydrido, alkyl, benzyl, alkenyl, alkynyl, alkoxycarbonyl, alkylcarbonyl, alkylsulfonyl, alkylimino, alkoxyimino, alkoxycarbonylimino, Rx-alkyl or Rx-alkenyl wherein Rx is halo, hydroxy, cyano, mono, di-, tri- or tetra(alkoxy), alkynyloxy, alkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylphosphonyl, alkylphosphinyl, halocarbonyl, alkylcarbonyl, hydroxycarbonyl, alkoxycarbonyl, alkenyloxycarbonyl, benzyloxycarbonyl, phenoxycarbonyl, phenylaminocarbonyl, alkylhydrazinocarbonyl, aminocarbonyl, alkenylaminocarbonyl, alkylaminocarbonyl, benzylaminocarbonyl, thiocarbonyl, phenylthiocarbonyl, alkylthiocarbonyl, alkoxyalkylthiocarbonyl, di(alkoxycarbonyl), alkylcarbonylalkoxycarbonyl, alkylsulfinylalokoxycarbonyl, alkoxycarbonylalkylcarbonyl, alkoxycarbonylalkylaminocarbonyl, hydroxycarbonylalkylaminocarbonyl, di, tri, tetra(alkoxy) carbonyl, alkoxyalkenyloxycarbonyl, alkylthioalkoxycarbonyl, alkylaminoalkoxycarbonyl, di(alkylamino)carbonyl, alkoxyalkylaminocarbonyl, alkoxyaminocarbonyl, alkylsulfonylaminocarbonyl, phenylsulfonylaminocarbonyl, alkoxycarbonylcarbonyloxy, alkoxycarbonylalkylcarbonyloxy, alkoxycarbonylamino, alkoxycarbonylalkylthio, alkoxycarbonylalkylaminocarbonyl, alkylcarbonylaminocarbonyl, alkylcarbonyloxydi(alkoxy)carbonyl, alkoxyalkylcarbonyloxydi(alkoxy)carbonyl, alkoxycarbonylcarbonyloxydi(alkoxy)carbonyl, alkoxycarbonylalkylcarbon(alkoxy)carbonyl, alkoxycarbonylaminoalkoxycarbonyl, alkylsulfonylalkoxy carbonyl, alkylsulfonylaminocarbonyl, alkylphosphonylalkoxycarbonyl, alkoxycarbonyloximinocarbonyl, alkoxyoximinocarbonyl, or alkyloximinocarbonyl.

R_(d), and R_(e) are independently selected from hydrido, alkyl, alkenyl, alkynyl, benzyl, phenyl, alkoxy, alkenyloxy, benzyloxy, hydridocarbonyl, alkylcarbonyl, phenylcarbonyl, alkylsulfonyl, aminocarbonyl, alkoxycarbonyl, alkoxyalkyl, alkylthioalkyl, alkylaminoalkyl, alkylsulfonylalkyl, halocarbonylalkyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, di-, tri-(alkoxy), phenylthioalkyl, di(alkylamino)alkyl, alkylphosphonyl alkyl or alkylsilylalkyl; or R_(d) is hydrido or alkyl and R_(e) is amino, alkylamino, phenylamino or alkoxycarbonylalkylamino; or R_(d) and R_(e) together are a cycloalkyl chain having 2 to 6 carbon atoms.

R_(g) is selected from hydrido, alkyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, alkylaminocarbonylalkyl, alkylthiocarbonylalkyl, di(alkoxy)carbonylalkyl, and di(alkoxycarbonyl)alkyl;

R_(f) is selected from hydrido, alkyl, and alkoxyalkyl;

R_(h) is hydrido, halo, alkyl, alkenyl, alkoxy, alkylamino, phenoxy, alkylaminocarbonyl, alkoxycarbonyl, hydroxycarbonylalkyl, alkoxycarbonylalkyl, alkylthio, alkoxycarbonylalkylthio and alkylsilylalkoxycarbonylalkyl or alkylsulfinylamino;

R_(i) and R_(j) are independently selected from hydrido, alkyl, alkoxy and alkylamino;

R_(k) is alkylphosphonyl, alkylaminoimino, alkylsulfinyl, alkylsulfonyl, alkylaminosulfonyl or halosulfonyl.

R_(a) through R_(j) can also comprise a heterocyclic substituent selected from triazolyl, morpholinyl, piperidyl, indolyl, piperazinyl, pyrrolidinyl, pyrazolyl, pyrrolinyl, azetidinyl, thienyl, imidazolyl, pyrimidinyl, furyl, pyridyl, tetrahydro2H-pyranyl, pyridinyl, pyrrolidinonyl, indazolyl, furanyl, dioxolanyl, 5,6-dihydro-1,4,2-dioxazinyl, tetrahydrofuranyl, tetrahydro-2-oxofuranyl, 4,5dihydro-4-oxofuranyl, benzimidazolyl, 4,5-dihydrooxazolyl, benzoxazolyl, piperidinyl, aziridinyl, 1H-2,5-dihydropyrrolyl, 1H-isoindole-1,3(2H)-dionyl, furanonyl, thiomorpholinyl, azepinyl or oxocyloalkyl, oxocycloalkenyl.

Preferred compounds of the present invention include compounds wherein R₁ is methyl; compounds wherein R₂ is halomethyl, methylsulfinyl or methylsulfonyl and most preferably where R₂ is halomethyl, especially difluromethyl or trifluoromethyl; compounds wherein R₃ is halo especially chloro and bromo.

Preferred compounds of the present invention have a Z which is ##STR3## and most preferably R_(c) O wherein R_(b), R_(c), R_(d), R_(e), R_(f) and R_(g) are as defined hereinabove. Z is preferably selected from alkoxy, haloalkoxy, bis(alkoxy), alkoxycarbonyl, alkoxycarbonylalkoxy, aminocarbonylalkoxy, alkylaminocarbonylalkoxy, alkylsulfonylaminocarbonylalkoxy, alkylamino, hydroxyalkylamino, alkoxyamino, alkoxyalkylamino, hydroxycarbonylalkylamino, and alkoxycarbonylalkyloxyimino.

The nature of the Z substituent is not critical to the presence of herbicidal activity for the unique class of compounds of the present invention. Compounds with other types of Z substituents are as follows:

(a) compounds according the Formula 1 with a Z substituent as defined above wherein substituents for R_(a) through R_(k) are selected from the collective group of substitutents recited above for R_(a) through R_(k) ; and (b) compounds according to Formula I with a Z substituent as defined above wherein R_(a) through R_(k) are substituents which comprise one or more radicals selected from carbonyl, oxy, amino, thio, carbonyloxy, carbonylamino, imino, oximino, sulfonyl, sulfinyl, thiocarbonyl, phosphinyl, phosphonyl, hydrazino, and the like and optionally also comprising bridging radicals selected from alkylene, phenyl and the like.

The phenyl ring can be optionally substituted in the other ring positions by one or more noninterferring substituents such as halo (e.g. as an ortho substituent, especially ortho halo) which do not unacceptably diminish the herbicidal activity. Compounds having such substituents are contemplated as equivalents of the compounds claimed herein.

The pyrazole ring can also be substituted in the 1-, 4- and 5-position by other substituents which do not unacceptably interfere with the herbicidal activity of the molecule. These compounds should also be contemplated as equivalents of those claimed herein.

The terms "di-, tri- and tetra-" mean that the referenced groups are polymeric such as di(methoxy) means CH₃ --O --CH--O--.

The term "alkyl" means herein a straight, branched and cyclic radical having 1 to 12 carbon atoms, preferably 1 to 5 carbon atoms and includes, but is not limited to, ethyl, methyl, 2-propyl, 1-ethylpropyl, 1-methylpropyl, n-butyl, 1,1-dimethylethyl, 2,2-dimethylpropyl, pentyl, 2-methylpropyl, 1-methylethyl and dodecyl. The cyclic alkyl radicals include cycloalkylalkyl radicals and alkylcycloalky radicals wherein the cyclic group of the radical has from 3 to 6 carbon atoms. Examples of cycloalkyl radicals are cyclopropyl, cyclopropylmethyl, methylcyclopropyl, cyclobutyl and cyclohexyl.

The terms "alkenyl" and "alkynyl" herein mean a straight, branched or cyclic group having 2 to 6 carbon atoms. Examples of such alkenyl groups include ethenyl, 1-propenyl, 2-propenyl, 1-butenyl, 2-butenyl, 3-butenyl, 2-methyll-propenyl, 2-methyl-2-propenyl, 1-methyl-ethenyl, and the like. Examples of such alkynyl groups include ethynyl, 1-propynyl, 2-propynyl, and so forth. The term "halo" is intended to mean fluoro, chloro, bromo or iodo.

The term "haloalkyl" is intended to mean an alkyl radical substituted with on or more halogen atoms preferably selected from bromo, chloro or fluoro. The term "alkoxycarbonyl" is intended to mean ##STR4## wherein R₁ is alkyl which may be substituted by a variety of substituents such as halo, hydroxy, nitro, cyano or the like. The term "alkylamino" is intended to mean R₁ R_(m) N-- wherein R_(m) is hydrido or lower alkyl wherein alkyl may also be substituted with a variety of substituents. The term "alkoxycarbonyl alkyl" is intended to mean ##STR5## The term "alkylthio" is intended to mean R₁ S-- and the term "alkylthiocarbonyl" is intended to mean ##STR6## The term "oximino" is intended to mean ##STR7## The term "alkylphosphonyl" and "alkylphosphinyl" are intended to mean, respectively ##STR8## The term "alkylsulfonyl" is intended to mean ##STR9## The term "alkylsulfinyl" means ##STR10## The term "imino" is intended to mean --C═N--.

Agriculturally acceptable salts of the present invention include alkali, alkaline earth, acid addition, base addition and alkylation salts. Generally, the salts will have suitable cations which include alkali metals such as sodium, potassium, and lithium; alkaline earth metals such as calcium, organic ammoniums and ammonium salts, sulfonium, phosphonium salts, and other salt complexes. Alkylation salts are generally formed by alkylation of nitrogen or sulfur atoms in the molecule.

The alkyl, alkenyl, alkynyl, phenyl and phenylalkyl radicals in the compounds of the present invention represented by Formula I can in turn be substituted by a variety of substituents which will not interfere with the biological activity of the compound in addition to those substituents which are specifically exemplified herein. Suitable substituents include for example substituents such as halo, cyano, nitro, amino hydroxy, haloalkyl, alkoxy, alkylthio, alkylsilyl, sulfonyl, phosphonyl and the like and such radicals in the compounds of the present invention with these substituents are intended to be within the scope of the claims of the present invention. Such substitution will normally only be mono, di or tri substitution ("mono/polysubstitution") on such radicals provided, however, in the case of halo and hydroxy, a greater degree of substitution may be suitable. Further, many of the compounds of the present invention may have more than one possible stereoisomer and structures illustrated are intended to include all such stereoisomers.

The procedures described below depict suitable methods whereby the compounds of this invention may be prepared by known chemical procedures from compounds which are known in the art and/or are readily available commercially. These procedures described below are merely illustrative and those skilled in the art will know a variety of other procedures for making the compounds of the present invention.

Compounds of the present invention can generally be prepared by two procedures, Procedure A or Procedure B. Certain compounds of the present invention are prepared by Procedure A in a two-step reaction as follows: (i) reacting 2,4-dichloronitrobenzene with at least two equivalents of the appropriately substituted 3-hydroxypyrazole in a suitable solvent and (ii) reacting the product of (i) with an appropriate nucleophilic reactant selected from oxides, thiolates and amines. Suitable oxides are hydroxide, alkoxides, phenoxides, and the like. Other compounds of the present invention can be prepared from these compounds using known chemical procedures.

The compounds of the present invention can also be prepared by Procedure B by reacting a 3-hydroxypyrazole intermediate with a 4-halonitrobenzene intermediate having the following structure: ##STR11## The halo atom on the nitrobenzene is preferably fluoro or chloro. W can be selected from a variety of substituents such as the desired substituent in the phenoxypyrazole product (the Z substituent) or a displaceable substituent such as fluoro which can be subsequently displaced from the phenoxypyrazole with the desired substituent.

Pyrazole Intermediate.

Certain of the 3-hydroxypyrazole intermediates used to make the compounds of the present invention are novel compounds. Such novel 3-hydroxypyrazoles having the following formula: ##STR12## wherein:

R₁ is methyl or ethyl;

R₂ is halomethyl, haloethyl, methylthio or ethylthio

Examples of such novel 3-hydroxypyrazoles.

5-Trifluoromethyl-4-methyl-3-hydroxy-1-methylpyrazole.

5-Difluoromethyl-4-methyl-3-hydroxy-1-methylpyrazole.

5-methyltio-4-methyl-3-hydroxy-1-methylpyrazole.

The 3-hydroxypyrazole intermediates can be conveniently prepared by the following processes. The 1,4-bismethyl-3-hydroxypyrazoles are conveniently made from 4-bromo-3-hydroxy-1-methylpyrazole which is in turn made from the corresponding 4-hydrido-3-hydroxy-1-methyl pyrazole.

The pyrazole intermediate is conveniently prepared by reacting an alkylhydrazine with an alkyl 3-haloalkylpropynoate which is in turn prepared generally in accordance with procedures set forth in Huang et al. Scientia Sinica 25, 21 (1982). The Huang phosphorane intermediate can be prepared by reacting (carbethoxymethyl)triphenylphosphonium bromide with trifluoroacetic anhydride in the presence of triethylamine and tetrahydrofuran.

The 5-trifluoromethyl-3-hydroxy-1-methylpyrazole intermediate may also be conveniently prepared by reacting ethyl 4,4,4-trifluoro-2-butynoate with methylhydrazine in a suitable solvent such as methylene chloride or methanol/water at a low temperature from about -78° C. to about -20° C. The reaction at higher temperatures will result in a mixture of the 3-hydroxy and 5-hydroxypyrazole isomers. It is believed that reduced temperatures and more polar solvents provide greater amounts of the desired 3-hydroxy isomer of the pyrazole. Prior to reacting the pyrazole with the nitrobenzene, it is generally preferred to purify the pyrazole to separate out the 5-hydroxypyrazole isomer. This purification can be easily accomplished by stirring the isomer mixture product in an aqueous solution of sodium bicarbonate. The 5-hydroxy isomer is dissolved into solution while the 3-hydroxy isomer remains in suspension and is readily separated.

An alternative method of forming 5-trifluoromethyl-3-hydroxy-1-methylpyrazole involves reacting ethyl 4,4,4-trifluoroacetoacetate in acetone with preferably triethylmethylammonium methylsulfate and with dimethyl sulfate in the presence of anhydrous potassium carbonate to form 3-methoxy-4,4,4-trifluoro-2-butenoic acid ethyl ester. This ester is then reacted directly with methylhydrazine to form the 3- and 5-hydroxy isomer mixture of the intermediate pyrazole. The desired isomer can be separated as described above.

Another method of making the 3-hydroxypyrazole involves reacting the ethyl 4,4,4-trifluoroacetoacetate directly with the methylhydrazine in ether to form a mixture of intermediates, 5-hydroxypyrazolidin-3-one and 3-hydroxypyrazolidin-5-one and dehydration of these intermediates by the addition of sulfuric acid in chloroform to form a mixture of the 3- and 5-hydroxypyrazoles. The desired isomer can be separated as described above.

Referring to procedure below, a preferred process for making 3-hydroxypyrazoles comprises reacting 3-(amino or substituted amino)-2-alkenoic acid or acid derivative with an alkyl substituted hydrazine. Suitable alkenoic acid derivatives included esters, thioesters and amides. In the procedure 1, Y is hydrido or halo, preferably fluoro and R is hydrido, alkyl or phenyl, preferably hydrido. The alkenoic acid can also have a methyl substituent in the 2-position. ##STR13##

A preferred method of forming the 5-trifluoromethyl-3-hydroxy-1-methylpyrazole involves bubbling ammonia gas through ethyl 4,4,4-trifluoroacetoacetate at an elevated temperature while removing water to form 3-amino-4,4,4-trifluoro-2-butenoic acid ethyl ester. This ester is then reacted directly with methylhydrazine to form the 3- and 5-hydroxy isomer mixture of the intermediate pyrazole. The desired isomer can be separated as described above.

Pyrazole intermediates having a 5-alkylthio (e.g., methylthio) and a 4-halo (e.g., chloro) substituent can be made by reacting methylhydrazine with alkyl 3-methylthio-2,3-dichloroacrylate and potassium carbonate in a suitable solvent.

The corresponding phenoxypyrazole having either a 5-alkylsulfinyl or a 5-alkylsulfonyl substituent can be made by oxidation of the corresponding 5-alkylthio-4-methylphenoxypyrazole with appropriate amounts of a suitable oxidizing agent such as m-chloroperbenzoic acid in a suitable solvent such as dichloromethane.

Except as described below, other pyrazole intermediates can be prepared generally in accordance with these procedures. The 1-ethylpyrazoles are also prepared generally in accordance with these procedures. The ethyl hydrazine is conveniently liberated from its oxalate salt in situ with a suitable base (e.g., triethylamine or sodium methoxide) during the reaction. Phenoxypyrazoles having N-bromodifluoromethyl or N-difluoromethyl substituents are made by reacting dibromodifluoromethane or chlorodifluoromethane, respectively, with a phenoxypyrazole having a N-hydridosubstituent which is made from the corresponding N-tetrahydropyranylpyrazole. Phenoxypyrazoles having N-trifluoromethyl substituents are made by reacting a N-bromodifluoromethylphenoxypyrazole with with AgBF₄.

The 5-haloalkyl-3-hydroxypyrazole intermediates can be chlorinated or brominated to form the corresponding 5-haloalkyl-4-halo-3-hydroxypyrazole intermediate. Suitable chlorinating/brominating agents include bromine, chlorine, sulfuryl chloride and sulfuryl bromide. Preferred chlorinating/brominating agents are 1,3-dichloro-5,5-dimethylhydantoin and 1, 3-dibromo-5, 5-dimethylhydantoin in a solvent such as diethyl ether.

The 4-methylpyrazole is generally formed from chemistry. In order to protect the 3-hydroxy group, the 4-bromopyrazole is reacted with trialkylsilylchloride and a base. The resulting 3-trialkylsiloxy4-bromopyrazole is then sequentially reacted with (i) n-butyl lithium at -78° C. in THF; (ii) methyl iodide and (iii) aqueous HF in acetonitrile to form the 4-methylpyrazole intermediate. The 4-methyl-3-hydroxy pyrazoles having a 5-methylthio substituent are made by (i) reacting 4-bromo-3-trialkylsiloxypyrazole sequentially with lithium tetramethylpiperidine and dimethylsulfide; and (ii) lithiation of the 4-position of the product of (i) and then reaction with methyliodide.

The 5-haloalkylpyrazole intermediates having 5-fluoromethyl or a 5-trichloromethyl substituent are made in a different manner. Pyrazole intermediates with a 5-fluoromethyl substituent are made from the corresponding 5-methoxy-carbonylpyrazole which is in turn prepared by reacting dimethyl acetylenedicarboxylate with methylhydrazine in ether. The 5-methoxycarbonylpyrazole is sequentially reduced with lithium aluminum hydride and fluorinated with dimethylaminosulfur trifluoride (DAST) to form the 5-fluoromethylpyrazole intermediate. The 5-trichloromethyl pyrazole can be made by suitable processed known to those skilled in the art such as by chlorination. The invention compounds having a 5-cyano substituent on the pyrazole ring are made from phenoxypyrazoles having a 5-hydrocarbonyl substituent. The compounds having the 5-hydrocarbonyl are made via lithiation chemistry as noted above by reaction with dimethylformamide. The 5-hydrocarbonyl phenoxypyrazole is then reacted with hydroxylamine and acetic anhydride to give the corresponding 5-cyano.

Those skilled in the art will appreciate that the 3-hydroxypyrazoles may exist in either of their tautomeric structures (the 3-hydroxypyrazole or the pyrazolidin-3-one) and the 3-hydroxypyrazole structure used herein is intended to mean both tautomeric structures.

Nitrobenzene Intermediates

The intermediate 2-(alkoxy or alkoxycarbonylalkoxy)-4-fluoronitrobenzenes are prepared from 2-hydroxy-4-fluoronitrobenzenes which are either commercially available or are prepared by reacting 2,4-difluoronitrobenzene with sodium hydroxide in DMSO and extracting the product from water with hexane. To form intermediate nitrobenzenes having an alkoxy or a haloalkoxy W substituent, the 2-hydroxy-4-fluoronitrobenzene is reacted with an appropriate alkylating agent (e.g., alkyl iodide), in a suitable solvent in the presence of a base. An alternative procedure for making a nitrobenzene intermediate having an alkoxy or alkylthio W substituent is to react 2,4-difluoronitrobenzene with sodium alkoxide or sodium alkylthiolate in a suitable solvent.

The intermediate nitrobenzenes with the alkoxycarbonylalkoxy W substituent are formed from 2-hydroxy-4-fluoronitrobenzene. 2-Hydroxy-4-fluoronitrobenzene is reacted with a haloalkylcarboxylate (e.g., ethyl 2-bromopropionate) in a suitable solvent in the presence of a base.

A procedure for making a nitrobenzene intermediate having an alkoxycarbonyl W substituent is to esterify the corresponding commercially available 5-chloro-2-nitrobenzoic acid.

The intermediate 4-fluoro-2-alkylaminonitrobenzenes are prepared by reacting the 2,4-difluoronitrobenzene with the appropriate amine in a suitable solvent. 4-Fluoronitrobenzene intermediates with an alkoxyamino substituent are made by reaction with the appropriate hydrogen chloride alkoxyamine salt in base. The 4-fluoro-2-hydrazinonitrobenzenes are made in a similar fashion.

Invention Compounds--General Procedure

Certain compounds of the present invention are prepared using Procedure A in a two-step reaction. The first step involves reacting 2,4-dichloronitrobenzene with a two molar excess of the appropriate 3-hydroxypyrazole in a suitable solvent such as DMSO or DMF with potassium carbonate under nitrogen at an elevated temperature. The product of step one, [2,4-bis(pyrazolyloxy)nitrobenzene] is then reacted with a nucleophilic reactant in a suitable coordination solvent such as glyme generally in the presence of a base. Suitable nucleophilic reactants include hydroxides, organic oxide salts, enolates, thiolates, ammonia, and primary and secondary amines and hydrazines. Suitable nucleophilic reactants are hydroxy, alkoxy, thio, alkylthio, amino, alkylamino, hydrazino, alkylhydrazino, alkoxyamino, and alkylaminooxy which are unsubstituted or substituted with one or more substituents selected from alkoxy, alkylamino, alkylthio, alkoxyalkyl, alkylaminoalkyl, alkylthioalkyl, halo, cyano and nitro.

Generally, it is convenient to form the organic oxides and thiolates as salts in a strong base for the reaction to proceed at a suitable rate. Primary and secondary amine nucleophilic reactants can be reacted with suitable bases such as potassium carbonate and in some cases, without a base.

In the process the pyrazole radical is substituted with substituents desired in the product.

Other compounds of the present invention are prepared using Procedure B by reacting an appropriate pyrazole intermediate with an appropriate halonitrobenzene intermediate to give the desired product generally in accordance with Procedure B below. ##STR14##

The pyrazole and halonitrobenzene are mixed together in the presence of a base such as potassium carbonate or potassium hydroxide in a suitable solvent such as DMSO, DMF or sulfolane at an elevated temperature.

A. Invention Compounds having R_(c) O as a Z Substituent

Compounds of the present invention having an R_(c) O such as an alkoxy substituent can be formed by reacting an alkali alkoxide such as sodium methoxide with the corresponding 2,4-bis(pyrazolyloxy)nitrobenzene in accordance with Procedure A. Compounds of the present invention having an R_(c) O such as alkoxy or alkoxycarbonylalkoxy as a Z substituent on the phenyl ring can be prepared by reacting the appropriate pyrazole intermediate with a halonitrobenzene intermediate having either an alkoxy or alkoxycarbonylalkoxy W substituent generally in accordance with Procedure B. Lastly, compounds having an R_(c) O as Z generally can be prepared by reacting the appropriate R_(c) OH with the corresponding phenoxypyrazole having a Z fluoro substituent or R_(c) X (where X is (i) halo selected from Cl, I or Br or (ii) X is CH₃ SO₂ O--) with the corresponding phenoxypyrazole having a Z hydroxy substituent.

Compounds having a hydroxy Z substituent are made by (a) reacting 2-methoxy-4-fluoronitrobenzene in accordance with Procedure B followed with demethylation with boron tribromide or (b) sequentially reacting the appropriate pyrazole with 2-(methylcarbonyloxy)-4-chloronitrobenzene in accordance with Procedure B and then hydrolysis by standard laboratory procedures. Compounds having alkoxycarbonylalkoxy as Z can also be made by reacting a haloacetate with a phenoxypyrazole having Z as a hydroxy. Compounds having Z as alkylaminoalkoxy can be made by reacting a phenoxypyrazole having Z as fluoro with a tertiary amine having a hydroxyalkyl substituent. Compounds having Z as alkylthioalkoxy, alkylsulfonylalkoxy and alkylphosphinylalkoxy are made in a like manner. A great variety of compounds of the present invention can be made by standard esterification of the corresponding acid chloride where Z is --O--CH(R)(CH₂)_(n) --COCl. Compounds of the present invention having an alkylcarbonylalkoxy as a Z substituent are formed by reacting an appropriate pyrazole intermediate with a nitrobenzene which has a corresponding ketal radical as a W substituent to protect the alkylcarbonylalkoxy group during the reaction. After forming the phenoxypyrazole product, acid is added to the reaction mixture to hydrolyze the ketal to give the corresponding alkylcarbonylalkoxy radical as a Z substituent. Compounds having Z as alkenyloxy can be made by dehydrobromination of the corresponding haloalkoxy compound which can be prepared by Procedure A. Compounds having as an alkylimino are made by reacting an invention compound with a Z fluoro with ketoxime. Compounds of the present invention having a phosphinyl Z substituent are made by the sequential reactions of (i) reacting a phosphonite with an aldehyde, (ii) reacting the product of (i) with trifluoromethanesulfonic anhydride (iii) reacting the the product of (ii) with 2-hydroxy4-fluoronitrobenzene and (iv) reacting the product of (iii) according to Procedure B.

B. Invention Compounds having ##STR15## as a Z Substituent

Compounds of the present invention having an alkoxycarbonyl as a Z substituent on the phenyl ring are made by reacting the appropriate pyrazole with a 4-halonitrobenzene having an alkoxycarbonyl W substituent generally in accordance with Procedure B.

Compounds of the present invention having the alkoxycarbonyl as a Z substituent are then converted into other compounds of the present invention which have derivative substituents of the alkoxycarbonyl substituent by transesterification or by hydrolysis of the alkoxycarbonyl substituent to form the corresponding carboxylic acid which can be (i) converted to other esters by esterification by standard laboratory procedures by forming the acid chloride and reacting it with the appropriate alcohol provided that hindered alcohols may require reaction with the sodium salt of the alcohol (e.g., alkenyloxycarbonyl substituents) or (ii) converted into aminocarbonyl compounds by sequential formation of the acid chloride and amination by standard laboratory procedures (e.g., alkylaminocarbonyl Z substituents); or (iii) converted into the thioesters by esterification of the acid chloride by standard laboratory procedures (e.g., alkylthiocarbonyl Z substituents); or (iv) converted into sulfonylaminocarbonyl compounds by sequential formation of the acid chloride and amination with a sulfonamide, neat, by standard laboratory procedures (e.g., alkylsulfonylaminocarbonyl as Z substituent) which can be N-alkylated by reaction with methyliodide and potassium carbonate in acetone; or (v) converted into oximinocarbonyl compounds by sequential formation of the acid chloride and reaction with a ketoxime (e.g., oximinocarbonyl as the Z substituent).

Compounds wherein R_(b) is alkyl are made by reacting a 4-fluoronitrobenzene intermediate having a 2-alkylcarbonyl substituent in accordance with Procedure B. Compounds where R_(b) is an alkoxyalkyl are made in the same manner wherein the nitrobenzene intermediate is made by reacting alkoxyalkylnitrile with 3-fluorophenyl magnesium bromide with subsequent nitration. Compounds wherein R_(b) is an oximino are prepared by reacting the corresponding acid chloride with N-hydroxyethyl acetimidate. Compounds wherein R_(b) is hydroxycarbonyl can be made by oxidizing the corresponding phenoxypyrazole having a Z methylcarbonyl substituent with selenium dioxide. Compounds wherein R_(b) is poly(alkoxy) are made by reacting the corresponding phenoxypyrazole with a bromoether or bromopolyether compound.

C. Invention Compounds with R_(a) as Z Substituent

A Variety of compounds having a R_(a) alkyl substituent can be made by reducing the invention compound with Z as chlorocarbonyl with sodium borohydride to the corresponding benzyl alcohol which, in turn, can be reacted with appropriate reactants to form compounds of the present invention having various types of substituted methyl radicals as Z. For example, the benzyl alcohol can be oxidized to the benzaldehyde. The Z iodomethyl compound is formed by sequentially reacting the benzyl alcohol with (i) methanesulfonyl chloride and (ii) sodium iodide. The compounds where Z is alkylaminoalkyl are made by reacting Z as iodomethyl with the appropriate amine. The Z-bromomethyl and chloromethyl compound can be made by reacting the corresponding alcohol with either phosphorus tribromide or thionyl chloride, respectively, in a suitable solvent. Compounds having a --CX₂ H as a Z substituent are conveniently made by halogenating the benzaldehyde with a suitable agent such as diethylaminosulfur trifluoride (DAST) or thionyl chloride. The procedure for making other substituted methyl radicals as Z will be known to those skilled in the art.

Compounds having a methyl or trifluoromethyl substituent as a Z substituent on the phenyl ring are made by reacting the appropriate pyrazole intermediate with either 2-methyl-4-halonitrobenzene or 2-trifluoromethyl-4-halonitrobenzene, respectively, in accordance with the Procedure B.

Other invention Compounds having an R_(a) substituent can be made by sequentially reacting the corresponding benzyl alcohol with methanesulfonyl chloride and then with appropriate nucleophiles such as alkoxides, amines or mercaptans in a base. Invention compounds having alkylcarbonyloxymethyl as a Z substituent can be made by reacting the corresponding benzyl alcohol with the appropriate acid choride. Compounds of the present invention having an alkoxycarbonylmethyl Z substituent are prepared by reacting the appropriate pyrazole with 2-alkoxycarbonylmethyl-4-fluoronitrobenzene generally in accordance with Procedure B. The corresponding acid, ester and amide derivatives can then be made by standard laboratory procedures. Compounds having Z as alkoxycarbonylethyl can be made by reacting the compound with Z amino sequentially with (i) t-butylnitrite and (ii) with methyl acrylate and CuCl₂. Compounds having alkenyl substituents can be made from the corresponding Z aldehyde compound generally in accordance with the Wittig reaction. Compounds having an alkynyl Z substituent can be made by reacting the corresponding Z hydroxy compound with trimethylsilylacetylene and bis(triphenylphosphine)paladium chloride. Compounds having Z cyanoalkyl or cyanoalkenyl substituents are made by reacting the corresponding aldehyde with cyanoacetic acid. Compounds having a Z cyano substituent are made from the corresponding 2-nitro-5-halo benzonitrile according to Procedure B.

Compounds having a Z methylthiomethyl substituent can be made by reacting the methanesulfonate of the benzyl alcohol with sodium methyl mercaptan.

D. Invention Compounds Having an R_(d) R_(c) N as a Z Substituent

Compounds of the present invention having an amino or hydrazino Z substituent are prepared by reacting the appropriate amino or hydrazino nuoleophilic reactant with (a) 2,4-bis(pyrazolyloxy)nitrobenzene generally in accordance with Procedure A or (b) with 2,4-difluoronitrobenzene to prepare the corresponding 2-amino or 2-hydrazino-4-fluoronitrobenzene or with the corresponding phenoxypyrazole having a Z fluoro substituent generally in accordance with the above displacement procedures. Compound having an aminocarbonylamino Z substituent can be made by reacting an invention compound having Z amino with chlorosulfonylisocyanate. Compounds having an alkyl phosphonylalkylamino Z substituent can be made by reacting the corresponding phenoxypyrazole with Z fluoro with diethyl 2-aminoalkylphosphonate.

E. Invention Compounds Having an ##STR16## Substituent

Compound of the present invention having an ##STR17## Z substituent can be prepared by two methods. The first method involves reacting a phenoxypyrazole having a methylcarbonyl Z substituent with 2-aminoxyacetic acid. The resulting carboxylic acid can be esterified by refluxing in a suitable alcohol in the presence of an acid catalyst such as toluenesulfonic acid. The acid may also be converted to amides and thioesters through the acid chloride.

These compounds can also be prepared by reacting the phenoxypyrazole having a loweralkylcarbonyl Z substituent with hydroxylamine hydrochloride and alkylation of the resulting oxime. Suitable methods for alkylation include treating the intermediate oxime with an alkyl halide (e.g, methyl iodide or methyl bromoacetate) and potassium carbonate in acetonitrile. The oxime can also be aIkylated under standard phase transfer conditions.

F. Invention Compounds having R_(h) S as a Z Substituent

Compounds of the present invention having R_(h) S as a Z substituent are made generally following the same procedures used for making compounds having amino Z substituents. Compounds having R_(h) as alkyl are made by reacting the Z fluorophenoxypyrazole with a mercaptan and the resulting 2 alkylthio-4-fluoronitrobenzene according to Procedure B. Compounds having Z as alkylaminothio, alkoxythio or the like are made by sequentially reacting the corresponding phenoxypyrazole having a Z-fluoro substituent with (i) Na₂ S₂ to form the disulfide (which can be reduced to Z as HS--), (ii) Cl₂ in CH₂ Cl.sub. (to form Z as SCl) and (iii) appropriate thiolate nucleophile such as mercaptans or the like with a base. Compounds having Z as alkylaminosulfonyl are formed in a similar manner except they are chlorinated in aqueous acetic acid. Compounds having Z as alkylaminocarbonylthio are made by reacting the phenoxypyrazole having a Z as HS-- substituent with an isocyanate.

G. Invention Compounds having an ##STR18## as a Z Substituent

Invention compounds having an imino Z substituent are prepared by reacting the phenoxypyrazole having a Z aldehyde group with an appropriate amine.

H. Invention Compounds having an R_(k) as a Z Substituent

Invention compounds having an R_(k) as a Z substituent can be made by a variety of methods known to those skilled in the art. Suitable methods are as follows. Thiocarbonyl compounds such as amino(thiocarbonyl) as Z can be made by reacting the corresponding carbonyl compound with phosphorus pentasulfide. Compounds having Z as an alkylsulfinyl and alkylsulfonyl can be made by oxidizing the corresponding alkylthio compound with m-chloroperbenzoic acid. Z imino compounds can be made by reacting compounds with Z amino with corresponding carbonyl.

I. Invention Compounds having an Ortho Substituent

Compounds having an ortho halo substituent (ortho to pyrazolyloxy) can be formed by reacting the appropriate pyrazole with 3,4-difluoronitrobenzene or 3,4,6-trifluoronitrobenzene according to Procedure B. The meta fluoro substituent (meta to the pyrazole) can then be displaced with hydroxide or alkoxide to form the corresponding phenol or alkoxide.

The following Examples 1-3 are detailed descriptions of methods of preparation of certain compounds of the present invention. These detailed preparations fall within the scope of, and serve to exemplify, the more generally described methods of preparation set forth above. These Examples are presented for illustrative purposes only and are not intended as a restriction on the scope of the invention. All parts are by weight unless otherwise indicated. Refractive indices are at room temperature.

EXAMPLE 1 ##STR19## 5-Trifluoromethyl-4-methyl-3-(3'-methoxy-4'-nitrophenoxy)-1-methylpyrazole.

(a) To a solution of 15 g (41.78 mmol) of 5-trifluoromethyl-4-bromo-3-(bismethyl-t-butylsiloxy)-1-methylpyrazole in tetrahydrofuran was added stoichiometric amount of 2.5M n-butyl lithium at -78° C. After 1/2 hour, the reaction was quenched with 18.38 ml of methyl iodide and warmed slowly to room temperature. The mixture was extracted with ether/water and the ether layer washed with water, dried, and evaporated to give 14.5 g of a clear liquid. The product was added to 150 ml of acetonitrile and 5 ml of concentrated aqueous HF and stirred for 10 minutes to give a solid product. (b) A mixture of 3.03 g (16.82 mmol) of the product of step (a), 2.88 g of 4-fluoro-2-methoxynitrobenzene (16.83 mmol), and 2.55 g of potassium carbonate (18.48 mmol) in 50 ml of dimethyl sulfoxide was heated to 80° C. for 10 hours. The reaction was then poured into 200 ml of cold water and stirred for 1-2 hours. The solution was extracted with ethyl acetate and the organic layer was dried, filtered, and evaporated to give a dark oil residue. Purification by radial chromatography (30% ethyl acetate-petroleum ether) gave 5.07 g (91%) of an oil product.

Elemental Analysis for C₁₃ H₁₂ N₃ O₄ F₃

    ______________________________________                                                   C          H      N                                                  ______________________________________                                         Calculated: 47.14        3.65   12.69                                          Found:      47.27        3.70   12.69                                          ______________________________________                                    

EXAMPLE 2 ##STR20## 5-Difluoromethyl-4-methyl-3-(3'-methoxy-4'-nitrophenoxy)-1-methylpyrazole

(a) To a solution of 15.4 g (45.16 mmol) of 5-difluoromethyl-4-bromo-3-(bismethyl-t-butylsiloxy)-1-methylpyrazole in anhydrous THF was added 18.06 ml of 2.5 molar n-butyl lithium at -78° C. The mixture was stirred for 1 hour with methyl iodide and warmed to room temperature. Ether was added and the ether layer was washed with water, dried and evaporated to give an oily residue. The residue was dissolved in 100 ml of acetonitrile and 5 ml of concentrated aqueous HF added to precipitate 2.8 g of a white solid mp 145°-146° C. (b) A mixture of 1.0 g of the product of step (a) (6.17 mmol), 4-fluoro-2-methoxynitrobenzene (1.06 g 6.17 mmol), and 0.94 g of potassium carbonate (6.79 mmol) in 50 ml dimethyl sulfoxide was heated to 80° C. for 15 hours. The reaction was then poured into 200 ml cold water and stirred for 1-2 hours. The precipitate formed was collected to give 1.8 g of a white solid product m.p. 57°-58° C.

Elemental Analysis for C₁₃ H₁₃ NL₃ O₄ F₂

    ______________________________________                                                   C          H      N                                                  ______________________________________                                         Calculated  49.84        4.18   13.41                                          Found       49.76        4.12   13.44                                          ______________________________________                                    

EXAMPLE 3 ##STR21## 5-Methylsulfonyl-4-methyl-3-(3'-methoxycarbonyl-4-nitrophenoxy)-1-methylpyrazole

(a) 17.12 g (58.83 mmol) of 4-bromo-3-(bismethyl-t-butylsiloxy)-1-methylpyrazole in anhydrous THF was added to a stoicheometric amount of 2.5M n-butyl lithium in THF at -78° C. and stirred for 1 hour. The solution was then added to 12.47 g of dimethyldisulfide in THF and warmed to room temperature. Ether was added and the ether layer washed with water dried and evaporated. The oily res(due was vacuum distilled at 109°-115° C. (0.22 torr) to give 18 g of a yellow oil.

(b) 12.0 g of the product of (a) was dissolved in 150 ml of acetonitrile and 5 ml of aqueous HF added and mixture stirred. About one-half of acetonitrile was removed and mixture cooled to precipitate 5.07 g of a solid. mp 109°-110° C.

(c) A mixture of 1.7 g of the product of step (b) (10.76 mmol), 2.32 g of methyl 5-chloro-2-nitrobenzoate (10.76 mmol), and 1.63 g of potassium carbonate (11.83 mmol) in 50 ml of dimethyl sulfoxide was heated to 80° C. for 10 hours. The reaction was then poured into 200 ml of cold water and stirred for 1-2 hours. The solution was extracted with ethyl acetate and the organic layer was dried, filtered, and evaporated to give a dark oily residue. Purification by radial chromatography (30% ethyl acetate-petroleum ether) gave 3.23 g of oil product of Example 8 (n.D.=1.586)

(d) A solution of 1.2 g (3.56 mmol) of the product of step (c) in 30 ml of dichloromethane was added slowly to a solution of 1.52 g of m-chloroperbenzoic acid (80% technical grade, 7.48 mmol) in 20 ml of the same solvent at ice temperature. The reaction was stirred at the same temperature for 15 hours and was then washed with aqueous sodium carbonate solution, aqueous sodium thiosulfate solution, and water. The organic layer was dried and evaporated to dryness. The resulting oily residue was purified by radial chromatography on a (30% ethyl acetate-petroleum ether) to give 1.0 g of final oil product containing 0.25 equivalents of ethyl acetate.

Elemental Analysis for C₁₄ H₁₅ N₃ O₇ S

    ______________________________________                                                   C          H      N                                                  ______________________________________                                         Calculated* 46.03        4.38   10.74                                          Found       46.12        4.34   10.95                                          ______________________________________                                          *Calculated including the ethyl acetate                                  

Using procedures similar to those set out in detail above, further compounds of the present invention were prepared and are shown in the following Table 1.

    __________________________________________________________________________     Ex                                                                             CP                                                                             #  Name                    Structure                                           __________________________________________________________________________     4  1H-pyrazole, 5-chloro-3-(3-methoxy-4- nitrophenoxy)-1,4-dimethyl- MP:          103.0-104.0 nD:                                                                                         ##STR22##                                          5  benzoic acid, 5-[[1,4-dimethyl-5-(trifluoromethyl)- 1H-pyrazol-3-yl]oxy        ]-2-nitro-,methyl ester MP: nD: 1.5210                                                                  ##STR23##                                          6  benzoic acid, 5-[[5-(difluoromethyl)-1,4-(dimethyl)- 1H-pyrazol-3-yl]ox        y]-2-nitro-,methyl ester MP: nD: 1.5696                                                                 ##STR24##                                          7  benzoic acid, 5-[[1,4-dimethyl-5-(methylsulfinyl)- 1H-pyrazol-3-yl]oxy]        -2-nitro-,methyl ester MP: nD:                                                                          ##STR25##                                          8  benzoic acid, 5-[[1,4-dimethyl-5-(methylthio)-1H- pyrazol-3-yl]oxy]-2-n        itro-,methyl ester MP: nD: 1.5860                                                                       ##STR26##                                          9  benzenamine, 5-[[1,4-dimethyl-5-(trifluoromethyl)- 1H-pyrazol-3-yl]oxy]        -N-methyl-2-nitro- MP: 61.0-64.0 nD:                                                                    ##STR27##                                          10 benzenamine, 5-[ [5-(difluoromethyl)-1,4-dimethyl- 1H-pyrazol-3-yl]oxy]        -N-methyl-2-nitro- MP: 109.0-110.0 nD:                                                                  ##STR28##                                          11 benzenamine, 5-[[1,4-dimethyl-5-(trifluoromethyl)- 1H-pyrazol-3-yl]oxy]        -N-methoxy-N-methyl-2-nitro- MP: nD: 1.4952                                                             ##STR29##                                          12 1H-pyrazole, 3-(3-methoxy-4-nitrophenoxy)-1,4- dimethyl-5-(methylsulfon        yl)- MP: 155.0-156.0 nD:                                                                                ##STR30##                                          13 1H-pyrazole, 3-(3-methoxy-4-nitrophenoxy)-1,4- dimethyl-5-(methylsulfin        yl)- MP: 119.0-120.0 nD:                                                                                ##STR31##                                          14 1H-pyrazole, 3-(3-methoxy-4-nitrophenoxy)-1,4- dimethyl-5-(methylthio)-         MP: 75.0-76.0 nD:                                                                                      ##STR32##                                          15 1H-pyrazole, 5-(difluoromethyl)-3-(3-ethoxy-4- nitrophenoxy)-1,4-dimeth        yl- MP: 77.0-78.0 nD:                                                                                   ##STR33##                                          16 propanoic acid,- 2-[5-[[5-difluoromethyl)-1,4-dimethyl-1H-pyrazol-3-           yl]oxy]-2-nitrophenoxy]-,ethyl ester MP: nD: 1.5210                                                     ##STR34##                                          17 propanoic acid,- 2-[5-[[1,4-dimethyl-5-(methylsulfonyl)-1H-pyrazol-            3-yl]oxy]-2-nitrophenoxy]-,ethyl ester MP: nD:                                                          ##STR35##                                          18 propanoic acid,- 2-[5-[[1,4-dimethyl-5-(methylsulfinyl)-1H-pyrazol-            3-yl]oxy]-2-nitrophenoxy]-,ethyl ester MP: nD: 1.5120                                                   ##STR36##                                          19 propanoic acid, 2-[5-[[1,4-dimethyl-5-(methylthio)- 1H-pyrazol-3-yl]           oxy]-2-nitrophenoxy]-,ethyl ester MP: nD: 1.5340                                                        ##STR37##                                          20 acetic acid,[[[1-[5-[[5-(difluoromethyl)-1,4-dimethyl- 1H-pyrazol-3-yl]        oxy]-2-nitrophenyl]ethylidene]- amino]oxy]-,propyl ester MP: nD:               1.5333                                                                                                  ##STR38##                                          21 benzenamine, 5-[[5-(difluoromethyl)-1,4-dimethyl- 1H-pyrazol-3-yl]oxy-N        -methoxy-N-methyl-2-nitro- MP:  nD: 1.5472                                                              ##STR39##                                          22 1H-pyrazole, 1,4-dimethyl-3-(4-nitrophenoxy)-5- (trifluoromethyl)- MP:         55.0-56.0 nD: --                                                                                        ##STR40##                                          23 1H-pyrazole, 1,4-dimethyl-3-(3-methyl-4- nitrophenoxy)-5-(trifluorometh        yl)- MP: 51.0-53.0 nD: --                                                                               ##STR41##                                          24 1H-pyrazole, 1,4-dimethyl-3-[4-nitro-3- (trifluoromethyl)phenoxy]-5-(tr        ifluoromethyl)- MP: 60.0 nD: --                                                                         ##STR42##                                          25 benzamide, 5-[[1,4-dimethyl-5-(trifluoromethyl)- 1H-pyrazol-3-yl]oxy]-N        -(2-hydroxyethyl)-2-nitro- MP: 159.0 nD: --                                                             ##STR43##                                          26 benzoic acid, 5-[[1,4-dimethyl-5- (trifluoromethyl)-1H-pyrazol-3-yl]oxy        ]-2-nitro,2,2- dimethylhydrazide MP: 157.0 nD: --                                                       ##STR44##                                          27 hydrazinium,- 2-[5-[[1,4-dimethyl-5-(trifluoromethyl)-1H-pyrazol-              3-yl]oxy]-2-nitrobenzoyl]-1,1,1-trimethyl-,iodide MP: 145.0 nD:                                         ##STR45##                                          28 oxazole, 2-[5-[[1,4-dimethyl-5-(trifluoromethyl)-1H- pyrazol-3-yl]oxy]-        2-nitrophenyl]-4,5-dihydro- MP: 87.0-88.0 nD: --                                                        ##STR46##                                          __________________________________________________________________________

PRE-EMERGENT ACTIVITY ON WEEDS

One set of pre-emergent tests was conducted as follows:

Topsoil was placed in a pan and compacted to a depth of 0.95 to 1.27 cm. from the top of the pan. A predetermined number of seeds of each of several monocotyledonous and dicotyledonous annual plant species and/or vegetative propagules of various perennial plant species were placed on top of the soil. The soil required to level fill a pan after seeding or adding vegetative propagules was weighed into another pan. A known amount of the test compound dissolved or suspended in an organic solvent or water and applied in acetone or water as a carrier was thoroughly mixed with this cover soil, and the herbicide/soil mixture was used as a cover layer for the previously prepared pan. In Table A below the amount of active ingredient was equivalent to an application rate of 11.2 kg/ha. After treatment, the pans were moved to a greenhouse bench where they were watered as needed to give adequate moisture for germination and growth.

Approximately 10-14 days (usually 14 days) after planting and treating, the pans were observed and the results recorded. In some instances, a second observation was made approximately 24-28 days after seeding and treating, and these observations are indicated in the following tables by a "pound" sign (#) immediately following the Example number.

The plant species usually regarded as weeds which were utilized in one set of pre-emergent activity tests, the data for which are shown in Table A, are identified by letter headings printed diagonally above the columns according to the following legend:

CATH--Canada thistle*

RHQG--Quackgrass*

COBU--Cocklebur

RHJG--Rhizome Johnsongrass*

VELE--Velvetleaf

DOBR--Downy Brome

MOGL--Morningglory

BYGR--Barnyardgrass

COLQ--Common Lambsquarters

ANBG--Annual Bluegrass

PESW--Pennsylvania Smartweed

SEJG--Seedling Johnsongrass

YENS--Yellow Nutsedge*

INMU--Indian Mustard

WIBW--Wild Buckwheat

In Table A, the first column is the application rate of the compound being tested in kg/ha.

PRE-EMERGENT HERBICIDE EXAMPLES

As noted above, compounds of this invention have been found to be effective as herbicides, particularly pre-emergent herbicides. Table A summarizes results of tests conducted to determine the pre-emergent herbicidal activity of the compounds of this invention. The herbicidal ratings used in Table A was assigned according to a scale based on the percent inhibition of each plant species.

                                      TABLE A                                      __________________________________________________________________________     Ex.                                                                               Rate                                                                        No.                                                                               kg/ha                                                                              Yens                                                                              Anbg                                                                               Sejg                                                                              Dobr                                                                               Bygr                                                                              Mogl                                                                               Cobu                                                                               Vele                                                                              Inmu                                                                              Wibw                                     __________________________________________________________________________      1 11.2100                                                                            90 100 100                                                                               100 100                                                                               90  70  100                                                                               100                                                                               100                                       2 11.2100                                                                            90 100 100                                                                               100 100                                                                               80  30  100                                                                               100                                                                               100                                       3 11.2100                                                                            70 10  60 70  100                                                                               80  80  100                                                                               100                                                                                90                                       4 11.2100                                                                            30 70  90 20   90                                                                               70  20  100                                                                                0  90                                       5 11.2100                                                                            90 100 100                                                                               100 100                                                                               90  90  100                                                                                90                                                                               100                                       6 11.2100                                                                            80 60  90 60  100                                                                               90  40  100                                                                                90                                                                                90                                       7 11.2100                                                                            60 10  70  0   90                                                                               70  40  100                                                                                20                                                                                60                                       8 11.2100                                                                            30 20  70 60  100                                                                               70  40  100                                                                                50                                                                                80                                       9 11.2100                                                                            70 100 100                                                                               100 100                                                                               90  70  100                                                                               100                                                                               100                                      10 11.2100                                                                            60 10  100                                                                               80  100                                                                               90  10  100                                                                               100                                                                               100                                      11 11.2100                                                                            80 100 100                                                                               100 100                                                                               100 90  100                                                                               100                                                                               100                                      12 11.2100                                                                            90 90  100                                                                               80  100                                                                               100 90  100                                                                               100                                                                               100                                      13 11.2100                                                                            70 50  80 60  100                                                                               90  20   80                                                                                90                                                                               100                                      14 11.2100                                                                            50 20  90 60  100                                                                               90  20  100                                                                                90                                                                               100                                      15 11.2100                                                                            100                                                                               90  100                                                                               100 100                                                                               80  60  100                                                                               100                                                                               100                                      16 11.2100                                                                            80  0  90 10   90                                                                               90  90   90                                                                                0  0                                       17 11.2100                                                                            90  0  70  0  100                                                                               80  30   90                                                                                80                                                                                20                                      18 11.2100                                                                            20  0   0  0   70                                                                               60  30   30                                                                                0  0                                       19 11.2100                                                                            60  0  90 20  100                                                                               80  20   80                                                                               100                                                                               100                                      20 11.2100                                                                            50  0  90 70  100                                                                               70  90  100                                                                               100                                                                                90                                      21 11.2100                                                                            70 90  100                                                                               90  100                                                                               100 70  100                                                                               100                                                                               100                                      22 11.2100                                                                            80 100 100                                                                               100 100                                                                               100 20  100                                                                               100                                                                               100                                      23 11.2100                                                                            80 100 100                                                                               100 100                                                                               90  50  100                                                                                90                                                                               100                                      24 11.2100                                                                            10 90  100                                                                               90  100                                                                               90  50  100                                                                                90                                                                                90                                      25 11.2100                                                                            20 10  80 20  100                                                                               90  80   50                                                                                70                                                                                80                                      26 11.2100                                                                            20  0  20  0   30                                                                               30   0   30                                                                                0  20                                      27 11.2100                                                                            30 90  100                                                                               30  100                                                                               80  100 100                                                                                70                                                                               100                                      28 11.2100                                                                            30 30  80 20  100                                                                               50  30  100                                                                               100                                                                               100                                      __________________________________________________________________________

POST-EMERGENT HERBICIDE EXAMPLES

The post-emergence herbicidal activity of compounds of this invention was demonstrated by greenhouse testing, and the results are shown in the following Table B.

As was the case with the pre-emergence data, the herbicidal ratings used in Table B was assigned according to a scale based on the precent inhibition of each plant species.

POST-EMERGENCE ACTIVITY ON WEEDS

Top soil was placed in pans having holes in the bottom and compacted to a depth of 0.95 to 1.27 cm. from the top of the pan. A predetermined number of seeds of each of several dicotyledonous and monocotyledonous annual plant species and/or vegetative propagules for the perennial plant species were placed on the soil and pressed into the soil surface. The seeds and/or vegetative propagules were covered with soil and leveled. The pans were then placed on a bench in the greenhouse and watered as needed for germination and growth. After the plants reached the desired age (9-16 days), each pan (except the control pans) was removed to a spraying chamber and sprayed by means of an atomizer. The spray solution or suspension contained about 0.4% by volume of an emulsifying agent and a sufficient amount of the candidate chemical to give an application rate of the active ingredient of 11.2 kg/ha while applying a total amount of solution or suspension equivalent to 1870 L/Ha (200 gallons/acre). The pans were returned to the greenhouse and watered as before and the injury to the plants as compared to those in control pans was observed at approximately 10-14 days (usually 14 days) and in some instances observed again at 24-28 days (usually 28 days) after spraying. These latter observations are designated by a "pound" sign (#) following the column of example numbers in the Table. The plant species used in this set of tests and the recorded data were the same as those in the first set of pre-emergence tests, and the plant identifying codes are the same as those shown for Table A.

                                      TABLE B                                      __________________________________________________________________________     Ex.                                                                               Rate                                                                        No.                                                                               kg/ha                                                                              Yens                                                                              Anbg                                                                               Sejg                                                                              Dobr                                                                               Bygr                                                                              Mogl                                                                               Cobu                                                                               Vele                                                                              Inmu                                                                              Wibw                                     __________________________________________________________________________      1 11.2100                                                                            50 100 100                                                                               100 100                                                                               100 60  100                                                                               60 100                                       2 11.2100                                                                            20 100 100                                                                               100 100                                                                               90  30  100                                                                               80 100                                       3 11.2100                                                                            40 40  80 90  90 100 90  100                                                                               50 100                                       4 11.2100                                                                             0 50  90 60  90 90   0  100                                                                               20 100                                       5 11.2100                                                                             0 100 100                                                                               100 100                                                                               100 100 100                                                                               60 100                                       6 11.2100                                                                            20 90  90 90  100                                                                               100 60  100                                                                                0 100                                       7 11.2100                                                                            20 40  60 50  60 100 60   90                                                                               10 100                                       8 11.2100                                                                            20 20  60 30  70 60  50   90                                                                               10 100                                       9 11.2100                                                                             0 100 100                                                                               100 100                                                                               100 50  100                                                                               100                                                                               100                                      10 11.2100                                                                            10 90  100                                                                               100 100                                                                               90  80  100                                                                               60 100                                      11 11.2100                                                                             0 100 100                                                                               100 100                                                                               100 100 100                                                                               100                                                                               100                                      12 11.2100                                                                            30 90  30 90  80 100 90  100                                                                               80 100                                      13 11.2100                                                                             0 10  50 10   0 100 50   90                                                                               70 100                                      14 11.2100                                                                            10 90  90 70  70 80  40  100                                                                               50 100                                      15 11.2100                                                                            10 100 100                                                                               100 100                                                                               90  70  100                                                                               90 100                                      16 11.2100                                                                            20 50  80 90  90 100 100 100                                                                               10  80                                      17 11.2100                                                                             0 60  50 70  60 90  80  100                                                                               50  80                                      18 11.2100                                                                             0 50  60 20  70 60  60   50                                                                               50  80                                      19 11.2100                                                                            20 50  50 30  60 70  80  100                                                                               30  80                                      20 11.2100                                                                            20 10  60 20  80 60  100 100                                                                               60  90                                      21 11.2100                                                                            30 60  90 20  90 80  30   90                                                                               20  90                                      22 11.2100                                                                            30 40  50 30  90 50  30  100                                                                               30 100                                      23 11.2100                                                                            40 90  90 50  90 90  40  100                                                                               50 100                                      24 11.2100                                                                            20 40  100                                                                               20  60 60  40   90                                                                               20  90                                      25 11.2100                                                                             0 30  20 20  20 30  40   30                                                                               10  90                                      26 11.2100                                                                             0 50  100                                                                               90  10 100 50  100                                                                               30  90                                      27 11.2100                                                                            20 60  100                                                                               90  80 100 100 100                                                                               50  90                                      28 11.2100                                                                            20 80  100                                                                               90  90 60  90  100                                                                               90 90                                       __________________________________________________________________________

PRE-EMERGENCE ACTIVITY ON WEEDS AND CROPS

In another set of tests, the pre-emergence activity of compounds of this invention was tested on weeds in the presence of crop plants. In these test the following procedure was used.

Topsoil is sieved to pass through a 1/2 inch (1.27 cm) screen. Fertilizer is added to the topsoil in some of the tests, while in testing other compounds the fertilizer is omitted. The mixture is then sterilized.

The topsoil mixture is placed in an aluminum pan compacted to a depth of about 1.27 cm. from the top of the pan. On the top of the soil is placed a predetermined number of seeds of each of several monocotyledonous and dicotyledonous plant species and where noted vegetative propagules of various perennial plant species. The soil required to level fill a pan after seeding or adding vegetative propagules is weighed into another pan. A known amount of the active ingredient is dissolved or suspended in acetone or a suitable organic solvent as a 1% solution or suspension and applied to the cover soil using a sprayer at the desired rate. The spray is thoroughly mixed with this cover soil, and the herbicide/soil mixture is used as a cover layer for the previously prepared pan. Untreated soil is used as a cover layer for control pans. Alternatively, the pans may be covered with the soil layer and the spray solution uniformly applied to the soil surface. When this latter method is used, the statement "surface application" accompanies the test data. In Table C below the amount of active ingredient applied is a kg/ha shown in the Table.

After the treatment, the pans are moved to a greenhouse bench. Moisture is supplied to each pan as needed for germination and growth. Growth of each species is observed and corrective measures (greenhouse fumigation, insecticide treatment and the like) are applied as needed.

Approximately 10-14 days (usually 13 days) after seeding and treating, the pans are observed and the results recorded. In some instances, a second observation is made (usually 24-28 days after seeding and treating, although this time interval is at the discretion of the observer), and these observations are indicated in the following tables by a "pound" sign (#) immediately following the Example number.

The pre-emergence data for weeds in the presence of crop plants is shown in the following Table C. In these tests, the plants are identified according to the following column headings:

    ______________________________________                                         SOBE   Soybean       VELE     Velvetleaf                                       SUBE   Sugarbeet     DOBR     Downy Brome                                      WHEZ   Wheat         PRMI     Proso Millet                                     RICE   Rice          BYGR     Barnyardgrass                                    GRSO   Grain Sorghum LACG     Large Crabgrass                                  COBU   Cocklebur     GRFT     Green Foxtail                                    WIBW   Wild Buckwheat                                                                               CORN     Corn                                             MOGL   Morningglory  COTZ     Cotton                                           HESE   Hemp Sesbanie RAPE     Oilseed Rape                                     COLQ   Common        JIWE     Jimsonweed                                              Lambsquarters COCW     Commom Chickweed                                 PESW   Pennsylvania                                                                   Smartweed                                                               ______________________________________                                    

                                      TABLE C                                      __________________________________________________________________________     EX. #                                                                              RATE                                                                               SOBE                                                                               COTZ                                                                               RAPE                                                                               COBU                                                                               WIBW                                                                               MOGL HESE                                                                               COCW VELE                                 __________________________________________________________________________      6  5.0000                                                                             100 95  100 99  100 100  100 100  100                                      1.0000                                                                             45  30  25  10  100 90   100 95   100                                      0.2500                                                                             25  35  30  0    60 30   85  30    95                                      0.0625                                                                             35  25  0   0    40 0    95   0    25                                      0.0156                                                                              0  15  0   0    0  0     0   0    0                                    7  5.0000                                                                             95  15  70  90  100 100  100 100  100                                      1.0000                                                                             70  45  45  90  100 95   90  55   100                                      0.2500                                                                             30  15  0   0    90 0    35   0    75                                   3  5.0000                                                                             100 95  95  95  100 100  100 100  100                                      1.0000                                                                             90  15  75  35  100 75   100 90   100                                      0.2500                                                                             50  25  35  0   100 70   95  95   100                                      0.0625                                                                             15   0  0   0    95 0    15   0    20                                      0.0156                                                                             25   0  0   0    60 0         0                                            0.0078                                                                             10  15  0   0       0     0   0    0                                   12  5.0000                                                                             100 75  100 85  100 100  99  100  100                                      1.0000                                                                             95  25  100 75  100 100  99  75   100                                  12  0.2500                                                                             25  10  65  0   100 30   90  90   100                                      0.0625                                                                              0  10  0   0    80 0     0   0    0                                       0.0156                                                                             30   0  0   0    0  0    25  30    30                                      0.0078                                                                             35   0  0   0    0  0     0   0    0                                   13  5.0000                                                                             90  15  90  85  100 100  95  100   95                                      1.000                                                                              65   0  55  30  100 85   65  75   100                                      0.2500                                                                             25      0   0   100 60   10  35    45                                      0.0625                                                                              0      0   0    0  0     0   0    0                                    8  5.0000                                                                             90  55  80  0   100 100  100 100  100                                      1.0000                                                                             55  30  45  30  100 90   95  85   100                                      0.2500                                                                              0   0  0   0    80 0    15  25    10                                      0.0625   0  0   0    55 0     0        0                                   14  5.0000                                                                             90  60  90  0   100 95   100 100  100                                      1.0000                                                                             75   0  70  30  100 70   85  90   100                                      0.2500                                                                              0   0  0   0    95 0     0   0    0                                       0.0625                                                                              0   0  0   0    0  0     0   0    0                                       0.0156  20  25  0    0  0     0   0    0                                   17  5.0000                                                                             55  65  85  45  100 100  90  25   100                                      1.0000                                                                              5  30  60  0    60 0    25   0    90                                      0.2500                                                                             25  30  10  0    30 0     0   0    25                                      0.0625                                                                              0   5  0   0    0  0     0   0    0                                   19  5.0000                                                                             35  100 90  70  100 100  85  35   100                                      1.0000                                                                              0   0  0   0    90 0    15   0    35                                      0.2500                                                                              0   0  0   0    55 0     0  35    0                                       0.0625                                                                              0   0  0   0    0  0     0   0    0                                   10  5.0000                                                                             95  90  100 90  100 95   100 100  100                                      1.0000                                                                             25  50  40  0    95 100  100 100  100                                      0.2500                                                                              0   0  0   0   100 0    95  90    55                                      0.0625                                                                              0   0  0   0    35 0     0   0    0                                       0.0156                                                                             20   0  0   0    0  0     0   0    0                                   15  5.0000                                                                             100 90  90  100 100 100  100 100  100                                      1.0000                                                                             45  55  35  0    90 100  95  70   100                                      0.2500                                                                             35  25  30  0   100 60   55  60    70                                      0.0625                                                                             20  50  0   0    55 0     0   0    0                                   15  0.0156                                                                             15  10  0   0    0        0   0    0                                       0.0078                                                                              0   0  0   0    0  0     0   0    0                                       5.0000                                                                              0  35  0   95   90 100  50  90   100                                      1.0000                                                                              0  50  0   30   25 75   35  35    60                                  16  0.2500                                                                             25   0  0   0    0  75    0   0    25                                  __________________________________________________________________________     EX. #                                                                              RATE                                                                               WHEZ GRSO CORN                                                                               DOBR PRMI BYGR LACG                                                                               GRFT                                  __________________________________________________________________________      6  5.0000                                                                             70   100  99  95   95   100  100 100                                       1.0000                                                                             0    45   15  45   0    40   90  100                                       0.2500                                                                             0    40   0   25   0     0   75  45                                        0.0625                                                                             0    70   0   25   0    20   45  65                                        0.0156                                                                             0     0   0   25   0     0   25  30                                     7  5.0000                                                                             60   90   45  90   65   100  100 100                                       1.0000                                                                             25   55   15  40   30   45   45  95                                        0.2500                                                                             0     0   0   20   0     0   35  75                                     3  5.0000                                                                             85   95   90  95   95   100  100 100                                       1.0000                                                                             25   75   35  65   35   70   90  100                                       0.2500                                                                             0    70   25  15   0    45   85  90                                        0.0625                                                                             0    35   0   10   25    0   60  65                                        0.0156                                                                             0     0   0   30   0     0   30   0                                        0.0078                                                                             15    0   10  20   0     0   20                                        12  5.0000                                                                             95   70   90  95   95   70   100 100                                       1.0000                                                                             70   55   55  90   45   65   100 90                                    12  0.2500                                                                             0    15   15  20   15   20   75  75                                        0.0625                                                                             0     0   0   25   0     0   35   0                                        0.0156                                                                             0     0   0    5   0     0    0  20                                        0.0078                                                                             0    30   0   25   0     0    0   0                                    13  5.0000                                                                             75   10   70  40   75    5   90  100                                       1.000                                                                              35    0   30  30   20    5   55  55                                        0.2500                                                                             0    15   0   15   50    0    0  45                                        0.0625                                                                             0         0    5   0     0    0   0                                     8  5.0000                                                                             20   70   25  30   15   75   100 100                                       1.0000                                                                             0    30   0    0   0    85   70  100                                       0.2500                                                                             0    15   0   10   0     0   25  90                                        0.0625                                                                             0         0   25   0    20    0  40                                    14  5.0000                                                                             40   60   10  10   100  55   90  100                                       1.0000                                                                             25   10   10  20   0    70   80  75                                        0.2500                                                                             0     0   0    0   0     0   15  30                                        0.0625                                                                             0     0   0    0   0     0    0   0                                        0.0156                                                                             10   15   0   10   0     0    0   0                                    17  5.0000                                                                             90   90   100 75   20   90   100 100                                       1.0000                                                                             30   35   70   5   0    25   55  85                                        0.2500                                                                             15   30   25   0   0    30    0  60                                        0.0625                                                                             0     0   0    0   0    25    0   0                                    19  5.0000                                                                             90   95   70  45   70   70   75  100                                       1.0000                                                                             0    60   5   20   0    25    0  55                                        0.2500                                                                             0     0   0    0   0     0    0  70                                        0.0625                                                                             0     0   0    0   0    10    0   0                                    10  5.0000                                                                             80   80   70  95   100  95   95  100                                       1.0000                                                                             30   40   30  45   55   60   98  100                                       0.2500                                                                             0    10   0    0   0    10   75  80                                        0.0625                                                                             0     0   0    0   40   40   10  55                                        0.0156                                                                             0     0   0   20   0    30    0  20                                    15  5.0000                                                                             90   98   100 100  100  99   100 100                                       1.0000                                                                             0    60   40  60   80   75   95  100                                       0.2500                                                                             0    25   10  40   10   45   90  90                                        0.0625                                                                             0    15   0   15   0    55   15  40                                    15  0.0156                                                                             0    15   0   20   0    25   15   0                                        0.0078                                                                             0    15   0    0   0     0    0   0                                        5.0000                                                                             55   100  99  65   50   90   100 70                                        1.0000                                                                             15   90   70  10   0    10   25  30                                    16  0.2500                                                                             0    50   0   20   0     0    0  20                                    __________________________________________________________________________

                                      TABLE C-1                                    __________________________________________________________________________     Ex.                                                                               Rate                                                                        No.                                                                               kg/ha                                                                              Sobe                                                                              Cotz                                                                              Rape                                                                              Cobu                                                                               Wibw                                                                               Mogl                                                                               Hese                                                                              Jiwe                                                                              Vele                                                                              Whez                                                                               Rice                                  __________________________________________________________________________      1 5.6050                                                                             85 75 95 85  100 95  100   100                                                                               80  60                                       5.6050                                                                             100                                                                               100                                                                               100                                                                               85  100 95  100   100                                                                               90  50                                       1.1210                                                                             70 65 55 40  100 90  100   100                                                                                0  45                                       1.1210                                                                             85 35 95 40  100 90  95    100                                                                               40  45                                       0.2803                                                                             80 N  55 30  100 70  95    100                                                                               10   5                                       0.2803                                                                             50 20 N  65  100 90  98     95                                                                               25  20                                       0.0701                                                                              0  0 30  0   90 30  85     80                                                                                0  10                                       0.0701                                                                             35 25 40 25   97 65  90     60                                                                               20   0                                       0.0175                                                                              5  0 30  0   35  0   0     25                                                                                0   0                                       0.0087                                                                              0  0  0  0   0   0   0     0  0   0                                     2 5.6050                                                                             100                                                                               80 100                                                                               90  100 95  100   100                                                                               85  90                                       1.1210                                                                             65 10 75 30  100 90  95    100                                                                               10  25                                       0.2803                                                                             15 10 45  0  100  0  35     0  0  10                                       0.0701                                                                             30 15  0  0   25 30   0     0  0   0                                       0.0175                                                                             15 N   0  0   0   0   0     0  0   0                                       0.0087                                                                              0  0  0  0   0   0   0     0  0  15                                     4 5.6050                                                                             25  5 40  0   95 70  50    100                                                                               35  20                                       1.1210                                                                             10  0 20  0   98  0   0     0  0   0                                       0.2803                                                                             15  0  0  0   0   0   0     0  0   0                                       0.0701                                                                              0  0  0  0   0   0   0     0  0   0                                     5 5.6050                                                                             95 85 100                                                                               90  100 95  100   100                                                                               35  90                                       5.6050                                                                             90 85 95 95  100 100 100   100                                                                               25  95                                       1.1210                                                                             90 70 65 75  100 75  100   100                                                                               15  80                                       1.1210                                                                             70 80 90  0   95 70  100   100                                                                               25  70                                       0.2803                                                                             15  0 35  0   95 45  95     95                                                                                0  20                                       0.2803                                                                             45 20 15 10  100 60  95     95                                                                                0  65                                       0.0701                                                                             10 25 40 20   98 60  90     75                                                                               10  25                                       0.0701                                                                             25  0 20  0   0   0  25     60                                                                                0   0                                       0.0175                                                                              0  0  0  0  N    0   0     10                                                                                0   0                                       0.0087                                                                              0  0  0  0  N    0   0     0  0   0                                     9 5.6050                                                                             95 40 95 75  100 100 100   100                                                                               70  70                                       5.6050                                                                             55 75 85 90  100 100 100   100                                                                               60  85                                       1.1210                                                                             25 N  90 30  100 80  95    100                                                                               10  25                                       1.1210                                                                             30 25 35 40  100 90  100   100                                                                               30  10                                       0.2803                                                                             35  0 40  0  100  0  75     70                                                                                0   0                                       0.2803                                                                             35 15 30 20  100 65  70     75                                                                               10  40                                       0.0701                                                                             15 20 10  5   95 60  55     35                                                                               20  35                                       0.0701                                                                              0 N  10  0   60  0  N      80                                                                                0  30                                       0.0175                                                                              0 30  0  0   0   0  20     30                                                                                0  15                                       0.0087                                                                              0  0  0  0   0   0   0     20                                                                                0   0                                    11 5.6050                                                                             99 90 100                                                                               95  100 100 100   100                                                                               80  45                                       5.6050                                                                             95 90 100                                                                               95  100 100 100   100                                                                               55  95                                       1.1210                                                                             65 75 70  0  100 70  99    100                                                                               15  10                                       1.1210                                                                             70 70 75 70  100 90  100   100                                                                               30  50                                       0.2803                                                                             15 35 40  0   90 35  80    100                                                                                0   0                                       0.2803                                                                             25 60 35 55  100 55  95    100                                                                               10  25                                       0.0701                                                                             55 65 15 55   95 50  90     90                                                                                0  10                                       0.0701                                                                             25 15  0  0   45  0  60     75                                                                                0   0                                       0.0175                                                                              0  0  0  0   0   0   0     0  0   0                                       0.0087                                                                              0  0  0  0   0   0   0     0  0   0                                    __________________________________________________________________________     Ex.                                                                               Rate                                                                        No.                                                                               kg/ha                                                                              Grso                                                                              Corn                                                                              Dobr                                                                               Prmi                                                                              Bygr                                                                              Lacg                                                                               Grft                                                                              Sube                                                                              Colq                                                                               Pesw                                                                              Cocw                                   __________________________________________________________________________      1 5.6050                                                                             90 95 100 100                                                                               100                                                                               100 100          100                                       5.6050                                                                             100                                                                               100                                                                               100 100                                                                               100                                                                               100 100          100                                       1.1210                                                                             60 90 100 95 100                                                                               100 100          95                                        1.1210                                                                             90 90 95  75 100                                                                               95  100          100                                       0.2803                                                                             60 70 95  70 100                                                                               90  100          85                                        0.2803                                                                             35 55 100 70 100                                                                               100 100          45                                        0.0701                                                                              0  0 60   0 85 70  80           30                                        0.0701                                                                             35 20 55  40 95 85  55           45                                        0.0175                                                                              0  0 20   0 70 10  60            0                                        0.0087                                                                              0  0  0   0  0 N    0           N                                       2 5.6050                                                                             90 100                                                                               100 100                                                                               100                                                                               100 100          100                                       1.1210                                                                             15 60 90  30 95 100 85           100                                       0.2803                                                                              0 20  0   0 95 95  35            0                                        0.0701                                                                              0  0  0   0 30 20  10           30                                        0.0175                                                                              0  0  0   0  0  0   0            0                                        0.0087                                                                              0  0  0   0  0  0   0            0                                      4 5.6050                                                                             25 30 40  25 90 95  100          95                                        1.1210                                                                              0 20 35  30 70 80  55            0                                        0.2803                                                                              0  0 30  20  0  0  15            0                                        0.0701                                                                              0  0  0  10  0  0   0            0                                      5 5.6050                                                                             90 98 95  100                                                                               100                                                                               100 100          100                                       5.6050                                                                             95 90 100 100                                                                               100                                                                               100 100          100                                       1.1210                                                                             85 90 90  100                                                                               100                                                                               99  100          99                                        1.1210                                                                             70 40 90  90 98 100 95           99                                        0.2803                                                                             15  5  0  50 90 40  90           55                                        0.2803                                                                             45 35 10  90 95 100 100          90                                        0.0701                                                                             30 20  0  70 90 10  65            0                                        0.0701                                                                              5 25  0   5 70 N    0           20                                        0.0175                                                                              0  0 N   20 45 25   0           30                                        0.0087                                                                              0  0  0  N  30  0  25            0                                      9 5.6050                                                                             95 95 100 90 100                                                                               100 100          100                                       5.6050                                                                             90 90 100 100                                                                               100                                                                               100 100          100                                       1.1210                                                                             55 35 100 75 100                                                                               100 100          100                                       1.1210                                                                             65 45 95  45 100                                                                               100 90           90                                        0.2803                                                                             20 10 50  30 90 45  75            0                                        0.2803                                                                             40 25 70  25 95 95  75            0                                        0.0701                                                                             15 15 20   0 70 65   0           N                                         0.0701                                                                              0  0  0  25 40   0 35            0                                        0.0175                                                                              0  0  0   0  0  0   0            0                                        0.0087                                                                              0  0  0   0 20  0  N             30                                    11 5.6050                                                                             95 100                                                                               100 100                                                                               100                                                                               100 100          100                                       5.6050                                                                             100                                                                               97 100 100                                                                               100                                                                               100 100          100                                       1.1210                                                                             60 80 100 90 100                                                                               100 99           95                                        1.1210                                                                             90 90 95  100                                                                               100                                                                               100 100          100                                       0.2803                                                                             65 55 60  40 90 95  90            0                                        0.2803                                                                             60 40 40  80 95 100 100          55                                        0.0701                                                                             70 60 20  70 90 98  60           40                                        0.0701                                                                             15 10 40  25 70 50  65           35                                        0.0175                                                                             N   0  0   0  0  0  20            0                                        0.0087                                                                              0  0  0   0  0  0   0            0                                     __________________________________________________________________________

POST-EMERGENCE ACTIVITY ON WEEDS AND CROPS

Compounds of this invention were tested for herbicidal activity on weed plants in the presence of crop plants according to the following procedure.

Topsoil is sieved through a screen having 1.27 cm openings. In some of the tests the soil was mixed with fertilizer, while in other tests the fertilizer was omitted. This mixture is sterilized and then placed in pans having holes in the bottom. The soil mixture is compacted to a depth of 1.27 cm. from the top of the pan. A predetermined number of seeds of each of several dicotyledonous and monocotyledonous annual plant species and/or vegetative propagules for the perennial plant species are placed on the soil and pressed into the soil surface. The seeds and/or vegetative propagules are covered and the pans are then placed on a greenhouse bench and watered as needed. After the plants reach the desired stage, 10 to 14 days, 1 to 3 true leaf stage, each pan (except the control pans) is removed to a spraying chamber and sprayed by means of an atomizer, operating at a spray pressure of 170.3 kPa (10 psig) at the application rates noted in Table D. In the spray solution is an amount of an emulsifying agent mixture to give a spray solution or suspension which contains about 0.4% by volume of the emulsifier. The spray solution or suspension contains a sufficient amount of the candidate chemical in order to give application rates of the active ingredient corresponding to those shown in Table D below while applying a total amount of solution or suspension equivalent to 1870 L/Ha (200 gallons/acre). The pans are returned to the greenhouse and watered from below and the injury to the plants as compared to the control pans is observed at approximately 10-14 days (usually 11 days) and in some instances observed again at 24-28 days (usually 25 days) after spraying. These latter observations are designated by a "pound" sign (#) following the column of example numbers in the Table.

The the following Table D the legends used to identify the plant species are the same as those used in the proceeding Table C.

                                      TABLE D                                      __________________________________________________________________________     EX. #                                                                              RATE                                                                               SOBE                                                                               COTZ                                                                               RAPE                                                                               COBU                                                                               WIBW                                                                               MOGL HESE                                                                               COCW VELE                                 __________________________________________________________________________     6   5.0000                                                                             80  100 95  100 100 100  100 90   100                                      1.0000                                                                             80  99  50  60  98  80   90  65   100                                      0.2500                                                                             40  100 10  50  90  50   80  40   80                                       0.0625                                                                             15  70  0   10  75  35   65  20   50                                       0.0156                                                                             15  70  0   5       50   60  0    20                                   7   5.0000                                                                             75  75  75  80  98  100  80  80   70                                       1.0000                                                                             80  60  60  50  90  99   75  50   75                                       0.2500                                                                             30  65  25  20  90  65   70  75   40                                       0.0625                                                                             20  25  0   0   50  50   35  50   25                                       0.0156                                                                             10  20  0   0   30  20   20  0    25                                   3   5.0000                                                                             95  100 100 100 99  100  100 90   100                                      1.0000                                                                             80  100 98  95  98  100  100 70   99                                       0.2500                                                                             75  100 75  98  90  98   99  50   99                                       0.0625                                                                             75  90  35  50  90  75   75  40   60                                       0.0156                                                                             25  75  5   35  75  75   70  20   35                                   12  5.0000                                                                             80  98  100 100 100 100  99  95   100                                  12  1.0000                                                                             80  100 80  100 99  100  100 80   100                                      0.2500                                                                             80  98  70  60  80  95   75  40   75                                       0.0625                                                                             60  75  30  30  90  95   75  25   65                                       0.0156                                                                             20  80  20  25  75  80   65  10   40                                       0.0039                                                                             10  35  0   0   40  25   30  0    20                                   13  5.0000                                                                             90  100 80  80  100 100  90  75   95                                       1.0000                                                                             80  75  70  35  98  100  75  60   70                                       0.2500                                                                             40  60  50  30  75  80   65  25   65                                       0.0625                                                                             15  35  25  0   100 60   10  20   25                                       0.0156                                                                             5   10  0   0   25  25   0   0    10                                   8   5.0000                                                                             80  100 90  60  100 100  100 95   100                                      1.0000                                                                             75  100 50  60  100 90   100 60   100                                      0.2500                                                                             30  75  25  35  80  95   80  50   90                                       0.0625                                                                             20  65  5   10  70  75   65  0    50                                   14  5.0000                                                                             90  100 98  50  100 100  80  75   100                                      1.0000                                                                             80  98  65  40  95  98   75  30   99                                       0.2500                                                                             50  70  40  20  75  100  50  10   70                                   14  0.0625                                                                             20  60  25  10  50  50   30  20   60                                       0.0156                                                                             15  50  5   5   35  30   20  0    35                                   18  5.0000                                                                             70  99  65  100 90  65   0   0    25                                       1.0000                                                                             35  70  35  25  65  25   0   0    25                                       0.2500                                                                             25  60  0   0   35  35   0   0    10                                       0.0625                                                                             0   40  0   0   0   0        0    0                                        0.0156                                                                             0   25  0   0   0   0    0   0    0                                    17  5.0000                                                                             75  100 75  100 98  100  100 5    100                                      1.0000                                                                             70  95  70  80  75  99   65  0    75                                       0.2500                                                                             20  75  25  50  60  80   35  0    60                                       0.0625                                                                             5   50  0   20  20  25   10  0    35                                       0.0156                                                                             0   35  0   10  0   20   0   0    10                                   19  5.0000                                                                             65  100 90  100 80  99   98  0    100                                      1.0000                                                                             25  100 25  60  80  80   30  0    100                                      0.2500                                                                             10  35  0   20  50  60   20  30   75                                       0.0625                                                                             5   30  0   10  20  35   10  0    65                                       0.0156                                                                             5   0   0   0   0   10   30  0    25                                   10  5.0000                                                                             80  100 100 100 100 100  100 75   100                                      1.0000                                                                             75  100 75  75  99  100  75  98   99                                       0.2500                                                                             30  80  35  50  75  75   70  20   75                                       0.0625                                                                             10  65  25  25  60  30   40  20   50                                       0.0156                                                                             10  25  0   10  40  20   35  0    25                                   15  5.0000                                                                             75  100 100 100 100 100  99  70   100                                      1.0000                                                                             70  100 70  70  99  80   75  60   100                                      0.2500                                                                             35  98  40  40  90  50   75  25   75                                       0.0625                                                                             10  75  0   25  70  25   65  0    50                                       0.0156                                                                             5   40  0   10  35  30   50  0    40                                       0.0039                                                                             0   20  0   0   0   0    20  0    20                                   16  5.0000                                                                             75  100 90  100 75  100  100 75   100                                      1.0000                                                                             65  100 25  100 70  95   75  20   100                                      0.2500                                                                             5   95  0   100 50  70   40  0    100                                      0.0625                                                                             0   75  0   60  30  40   25  0    65                                       0.0156                                                                             0   35  0   10  0   0    0   0    30                                   __________________________________________________________________________     EX. #                                                                              RATE                                                                               WHEZ GRSO                                                                               CORN                                                                               DOBR PRMI BYGR LACG GRFT                                  __________________________________________________________________________     6   5.0000                                                                             10   30  70  70   25   60   95   80                                        1.0000                                                                             10   10  50  80   10   25   75   60                                        0.2500                                                                             5    10  40  60   10   20   30   35                                        0.0625                                                                             5    10  35  50   5    5    10   25                                        0.0156                                                                             0    5   25  30   0    5    10   20                                    7   5.0000                                                                             10   10  30  35   20   10   25   30                                        1.0000                                                                             10   5   30  30   10   10   10   25                                        0.2500                                                                             10   10  30  40   5    20   10   25                                        0.0625                                                                             5    0   25  20   0    5    25   20                                        0.0156                                                                             0    0   20  10   0    0    10   5                                     3   5.0000                                                                             20   35  50  40   25   30   50   30                                        1.0000                                                                             20   20  50  35   25   20   35   35                                        0.2500                                                                             10   5   35  10   10   10   10   30                                        0.0625                                                                             5    5   25  20   10   10   20   20                                        0.0156                                                                             10       25  30   10   10   20   20                                    12  5.0000                                                                             20   25  40  40   25   25   40   25                                    12  1.0000                                                                             20   25  30  60   25   25   35   30                                        0.2500                                                                             10   0   25  50   25   10   10   25                                        0.0625                                                                             5    0   25  20   10   20   10   25                                        0.0156                                                                             5    0   20  30   5    5    20   20                                        0.0039                                                                             0    0   10  10   0    0    10   10                                    13  5.0000                                                                             20   10  30  35   25   40   25   40                                        1.0000                                                                             10   0   25  60   20                                                       0.2500                                                                             10   5   35  40   10   10   35   35                                        0.0625                                                                             0    0   20  25   0    20   10   10                                        0.0156                                                                             0    0   10  5    0    5    5    10                                    8   5.0000                                                                             10   20  35  50   25   35   35   90                                        1.0000                                                                             10   30  30  70   20   35   25   75                                        0.2500                                                                             5    10  25  60   20   25   10   75                                        0.0625                                                                             0    0   25  25   5    10   10   30                                    14  5.0000                                                                             10   10  50  40   25   25   30   30                                        1.0000                                                                             10   5   40  40   20   20   25   35                                        0.2500                                                                             10   0   40  50   10   10   25   25                                    14  0.0625                                                                             0    0   25  40   0    10   20   25                                        0.0156                                                                             0    0   25  20   0    5    30   20                                    18  5.0000                                                                             35   5   30  50   10   20   60   75                                        1.0000                                                                             25   5   25  20   0    0    5    25                                        0.2500                                                                             10   0   20  25   0    0    0    0                                         0.0625                                                                             0    0   0   10   0    0    0    0                                         0.0156                                                                             0    0   0   0    0    0    0    0                                     17  5.0000                                                                             25   25  40  70   10   30   80   75                                        1.0000                                                                             20   10  35  35   10   20   40   40                                        0.2500                                                                             10   20  25  50   0    5    30   20                                        0.0625                                                                             5    10  20  50   0    0    0    0                                         0.0156                                                                             0    0   5   15   0    0    5    0                                     19  5.0000                                                                             35   20  30  90   10   25   30   50                                        1.0000                                                                             25   10  25  60   10   10   25   50                                        0.2500                                                                             10   10  25  30   0    0    20   25                                        0.0625                                                                             5    10  35  20   0    0    0    10                                        0.0156                                                                             0    0   0   5    0    0    0    0                                     10  5.0000                                                                             20   20  80  60   30   25   99   98                                        1.0000                                                                             10   20  50  65   25   25   50   75                                        0.2500                                                                             10   40  25  25   20   5    20   20                                        0.0625                                                                             5    25  20  10   5    0    0    30                                        0.0156                                                                             0    0   25  30   0    0    10   20                                    15  5.0000                                                                             20   20  90  65   80   90   100  100                                       1.0000                                                                             10   20  50  25   25   50   70   99                                        0.2500                                                                             5    10  30  50   10   25   25   50                                        0.0625                                                                             10   10  25  60   10   5    20   25                                        0.0156                                                                             0    10  30  35   5    5    10   25                                        0.0039                                                                             0    0   20  10   0    0    10   0                                     16  5.0000                                                                             10   20  80  75   30   35   90   40                                        1.0000                                                                             10   20  75  65   25   30   70   35                                        0.2500                                                                             5    15  35  50   10   10   40   20                                        0.0625                                                                             0    20  20  50   0    10   10   30                                        0.0156                                                                             0    0   5   10   0    0    0    0                                     __________________________________________________________________________

                                      TABLE D-1                                    __________________________________________________________________________            S C  R  C W  M H  J V  W R G C D P B  L  G  S  C  P  C                         o o  a  o i  o e  i e  h i r o o r y  a           r                                                                              u                                                                              o                                                                              e  o                  Ex.                                                                               Rate                                                                               b t  p  b b  g s  w l  e c s r b m g  c           f                                                                              b                                                                              l                                                                              s  c                  No.                                                                               kg/ha                                                                              e z  e  u w  l e  e e  z e o n r i r  g           t                                                                              e                                                                              q                                                                              w  w                  __________________________________________________________________________     1  5.6050                                                                             95                                                                               100                                                                               95 80                                                                               100                                                                               95                                                                               100  100                                                                               60                                                                               30                                                                               95                                                                               95                                                                               90                                                                               90                                                                               100                                                                               100                                                                               100         100                   1.1210                                                                             75                                                                               95 75 60                                                                               100                                                                               85                                                                               95   100                                                                               35                                                                               30                                                                               75                                                                               90                                                                               75                                                                               75                                                                               90 90          85 95                    0.2803                                                                             35                                                                               75 35 40                                                                               95 65                                                                               40   70 20                                                                               5 35                                                                               20                                                                               75                                                                               40                                                                               75 80          75 65                    0.0701                                                                             10                                                                               65 20 35                                                                               75 70                                                                               40   55 10                                                                               5 25                                                                               40                                                                               30                                                                               25                                                                               40 75          70 60                    0.0175                                                                             10                                                                               65 20 5 95 10                                                                               10   5  0 5 30                                                                               30                                                                               30                                                                               15                                                                               25 75          35 75                    0.0044                                                                             5 30 5  5 10 5 10   5  10                                                                               5 25                                                                               20                                                                               35                                                                               5 15 65          35 0                  2  5.6050                                                                             90                                                                               99 100                                                                               90                                                                               100                                                                               99                                                                               95   100                                                                               45                                                                               30                                                                               65                                                                               90                                                                               70                                                                               65                                                                               99 70          99 90                    1.1210                                                                             70                                                                               100                                                                               75 35                                                                               90 75                                                                               75   100                                                                               20                                                                               25                                                                               45                                                                               75                                                                               25                                                                               45                                                                               70 35          85 75                    0.2803                                                                             60                                                                               90 20 40                                                                               85 70                                                                               70   95 15                                                                               10                                                                               35                                                                               90                                                                               10                                                                               30                                                                               55 40          15 70                    0.0701                                                                             20                                                                               65 0  15                                                                               70 20                                                                               65   35 10                                                                               N 20                                                                               40                                                                               10                                                                               10                                                                               40 65          25 25                    0.0175                                                                             10                                                                               40 0  10                                                                               25 5 10   10 5 5 15                                                                               70                                                                               15                                                                               5 5  5           10 10                 4  5.6050                                                                             10                                                                               5  20 20                                                                               30 5 5    40 10                                                                               0 10                                                                               5 10                                                                               0 10 20          20 0                     1.1210                                                                             10                                                                               0  0  0 20 25                                                                               0    30 5 0 20                                                                               5 20                                                                               5 0  10          40 0                     0.2803                                                                             10                                                                               0  0  0 0  0 0    20 0 0 10                                                                               0 0 0 0  0           20 0                     0.0701                                                                             0 0  20 10                                                                               0  5 0    30 0 0 25                                                                               0 0 0 0  0           0  0                  5  5.6050                                                                             99                                                                               100                                                                               95 99                                                                               90 90                                                                               100  100                                                                               10                                                                               10                                                                               75                                                                               70                                                                               50                                                                               80                                                                               90 98          90 100                   1.1210                                                                             40                                                                               98 35 70                                                                               80 50                                                                               99   100                                                                               5 25                                                                               40                                                                               25                                                                               35                                                                               30                                                                               75 75          75 80                    0.2803                                                                             60                                                                               70 100                                                                               90                                                                               98 75                                                                               75   90 20                                                                               20                                                                               25                                                                               25                                                                               20                                                                               20                                                                               35 40          60 65                    0.0701                                                                             10                                                                               30 10 35                                                                               50 20                                                                               40   40 10                                                                               20                                                                               20                                                                               35                                                                               20                                                                               10                                                                               20 20          20 50                    0.0175                                                                             5 10 20 20                                                                               N  20                                                                               25   25 10                                                                               0 10                                                                               20                                                                               0 0 10 10          10 0                     0.0044                                                                             0 0  0  10                                                                               0  10                                                                               10   25 0 N 10                                                                               0 0 0 10 0           10 0                  9  5.6050                                                                             60                                                                               100                                                                               99 90                                                                               100                                                                               80                                                                               100  100                                                                               15                                                                               25                                                                               50                                                                               25                                                                               70                                                                               75                                                                               80 100         80 98                    1.1210                                                                             20                                                                               80 30 30                                                                               100                                                                               60                                                                               75   99 10                                                                               25                                                                               50                                                                               5 30                                                                               35                                                                               80 65          70 65                    0.2803                                                                             25                                                                               30 20 25                                                                               N  40                                                                               40   80 10                                                                               10                                                                               20                                                                               15                                                                               10                                                                               20                                                                               25 25          35 20                    0.0701                                                                             5 25 0  40                                                                               N  30                                                                               30   30 0 5 25                                                                               20                                                                               10                                                                               10                                                                               10 10          10 10                    0.0175                                                                             0 5  0  10                                                                               30 10                                                                               10   25 0 0 10                                                                               0 20                                                                               10                                                                               0  20          10 0                     0.0044                                                                             5 0  5  25                                                                               20 10                                                                               25   30 0 0 10                                                                               5 0 0 0  10          20 0                  11 5.6050                                                                             50                                                                               75 100                                                                               80                                                                               100                                                                               70                                                                               100  100                                                                               15                                                                               20                                                                               75                                                                               80                                                                               40                                                                               50                                                                               80 99          80 95                    1.1210                                                                             20                                                                               65 25 30                                                                               75 40                                                                               75   98 0 5 35                                                                               40                                                                               30                                                                               20                                                                               70 50          70 N                     0.2803                                                                             10                                                                               35 5  20                                                                               70 30                                                                               40   50 0 5 10                                                                               10                                                                               10                                                                               10                                                                               0  10          40 20                    0.0701                                                                             5 10 5  10                                                                               N  20                                                                               20   30 5 0 10                                                                               20                                                                               0 0 0  0           20 30                    0.0175                                                                             0 10 10 5 N  10                                                                               0    5  0 0 10                                                                               0 0 0 0  0           10 0                     0.0044                                                                             0 0  0  0 0  0 0    0  0 0 5 0 0 0 0  0           0  0                  __________________________________________________________________________

As can be seen from the data above, the compounds have good herbicidal activity and are safe on certain crops and can thus be used for selective control of weeds in these crops. Certain compounds of the present invention (Ex 1 and 2) have high herbicidal activity at low application rates for resulting cost swings and lower pesticide load on the environment.

The herbicidal compositions of this invention, including concentrates suitable for transportation which require dilution prior to application, and dilute composition suitable for application generally in accordance with concentrations set forth below. Compositions may contain at least one active ingredient and an adjuvant in liquid or solid form. The compositions are prepared by admixing the active ingredient with an adjuvant including diluents, extenders, carriers, and conditioning agents to provide compositions in the form of finely-divided particulate solids, granules, pellets, solutions, dispersions or emulsions. Thus, it is believed that the active ingredient could be used with an adjuvant such as a finely-divided solid, a liquid of organic origin, water, a wetting agent, a dispersing agent, an emulsifying agent or any suitable combination of these.

Suitable wetting agents are believed to include alkyl benzene and alkyl naphthalene sulfonates, sulfated fatty alcohols, amines or acid amides, long chain acid esters of sodium isothionate, esters of sodium sulfosuccinate, sulfated or sulfonated fatty acid esters, petroleum sulfonates, sulfonated vegetable oils, ditertiary acetylenic glycols, polyoxyethylene derivatives of alkylphenols (particularly isooctylphenol and nonylphenol) and polyoxyethylene derivatives of the mono-higher fatty acid esters of hexitol anhydrides (e.g., sorbitan). Preferred dispersants are methyl, cellulose, polyvinyl alcohol, sodium lignin sulfonates, polymeric alkyl naphthalene sulfonates, sodium naphthalene sulfonate, polymethylene bisnaphthalene sulfonate and polyethyleneoxide-polypropyleneoxide copolymers.

Wettable powders are water-dispersible compositions containing one or more active ingredients, an inert solid extender and one or more wetting and dispersing agents. The inert solid extenders are usually of mineral origin such as the natural clays, diatomaceous earth and synthetic minerals derived from silica and the like. Examples of such extenders include kaolinites, attapulgite clay and synthetic magnesium silicate. The wettable powders compositions of this invention usually contain from above 0.5 to 60 parts (preferably from 5-20 parts) of active ingredient, from about 0.25 to 25 parts (preferably 1-15 parts) of wetting agent, from about 0.25 to 25 parts (preferably 1.0-15 parts) of dispersant and from 5 to about 95 parts (preferably 5-50 parts) of inert solid extender, all parts being by weight of the total composition. Where required, from about 0.1 to 2.0 parts of the solid inert extender can be replaced by a corrosion inhibitor or anti-foaming agent or both.

Other formulations include dust concentrates comprising from 0.1 to 60% by weight of the active ingredient on a suitable extender; these dusts may be diluted for application at concentrations within the range of from about 0.1-10% by weight.

Aqueous suspensions or emulsions may be prepared by stirring a nonaqueous solution of a water-insoluble active ingredient and an emulsification agent with water until uniform and then homogenizing to give stable emulsion of very finely-divided particles. The resulting concentrated aqueous suspension is characterized by its extremely small particle size, so that when diluted and sprayed, coverage is very uniform. Suitable concentrations of these formulations contain from about 0.1-60% preferably 5-50% by weight of active ingredient, the upper limit being determined by the solubility limit of active ingredient in the solvent.

Concentrates which are suitable for transportation are usually solutions of active ingredient in water-immiscible or partially water-immiscible solvents together with a surface active agent. Suitable solvents for the active ingredient of this invention include dimethylformamide, dimethylsulfoxide, N-methylpyrrolidone, hydrocarbons, and waterimmiscible ethers, esters, or ketones. However, other high strength liquid concentrates may be formulated by dissolving the active ingredient in a solvent then diluting, e.g., with kerosene, to spray concentration.

The concentrate compositions herein generally contain from about 0.1 to 95 parts (preferably 5-60 parts) active ingredient, about 0.25 to 50 parts (preferably 1-25 parts) surface active agent and where required about 4 to 94 parts solvent, all parts being by weight based on the total weight of emulsifiable oil.

Granules are physically stable particulate compositions comprising active ingredient adhering to or distributed through a basic matrix of an inert, finely-divided particulate extender. In order to aid leaching of the active ingredient from &he particulate extender, a surface active agent such as those listed hereinbefore can be present in the composition. Natural clays, pyrophyllites, illite, and vermiculite are examples of operable classes of particulate mineral extenders. The preferred extenders are the porous, absorptive, preformed particles such as preformed and screened particulate attapulgite or heat expanded, particulate vermiculite and the finelydivided clays such as kaolin clays, hydrated attapulgite or bentonitic clays. These extenders are sprayed or blended with the active ingredient to form the herbicidal granules.

The granular compositions of this invention may contain from about 0.1 to about 30 parts by weight of active ingredient per 100 parts by weight of clay and 0 to about 5 parts by weight of surface active agent per 100 parts by weight of particulate clay.

The compounds of the present invention appear to show the greatest activity when applied as a postemergence herbicide. Further, when applied as a preplant incorporated, the activity appears to decrease with increasing organic matter in the soil.

The compositions of this invention can also contain other additaments, for example, fertilizers, other herbicides, other pesticides, safeners and the like used as adjuvants or in combination with any of the above-described adjuvants. Chemicals useful in combination with the active ingredients of this invention included, for example, triazines, ureas, carbamates, acetamides, acetanilides, dinitroanilines uracils, acetic acid or phenol derivatives, thiolcarbamates, triazoles, benzoic acids, nitriles, biphenyl ethers and the like such as:

Heterocyclic Nitrogen/Sulfur Derivatives

2-Chloro-4-ethylamino-6-isopropylamino-s-triazine

2-Chloro-4,6-bis(isopropylamino)-s-triazine

2-Chloro-4,6-bis(ethylamino)-s-triazine

3-Isopropyl-1H-2,1,3-benzothiadiazin-4-(3H)-one 2,2 dioxide

3-Amino-1,2,4-triazole

6,7-Dihydrodipyrido(1,2-α:2',1'-c)-pyrazidiinium salt

5-Bromo-3-isopropyl-6-methyluracil 1,1'-Dimethyl-4,4'-bipyridinium

2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-quinolinecarboxylic acid

Isopropylamine salt of 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid

Methyl 6-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-m-toluate and methyl 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-p-toluate

Ureas

N-(4-chlorophenoxy) phenyl-N,N-dimethylurea

N,N-dimethyl-N'-(3-chloro-4-methylphenyl) urea

3-(3,4-dichlorophenyl)-1,1-dimethylurea

1,3-Dimethyl-3-(2-benzothiazolyl) urea

3-(p-Chlorophenyl)-1,1-dimethylurea

1-Butyl-3-(3,4-dichlorophenyl)-1-methylurea

2-Chloro-N[(4-methoxy-6-methyl-1,3,5-triazin-2-yl) aminocarbonyl]-benzenesulfonamide

Methyl 2-(((((4,6-dimethyl-2-pyrimidinyl)amino)-carbonyl)amino)sulfonyl) benzoate

Ethyl 2-[methyl 2-(((((4,6-dimethyl-2-pyrimidinyl)-amino)carbonyl)amino)sulfonyl)]benzoate

Methyl-2((4,6-dimethoxy pyrimidin-2-yl)aminocarbonyl)aminosulfonyl methyl) benzoate

Methyl 2-(((((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)amino)sulfonyl) benzoate classic

Carbamates/Thiolcarbamates

2-Chloroallyl diethyldithiocarbamate

S-(4-chlorobenzyl)N,N-diethylthiolcarbamate

Isopropyl N-(3-chlorophenyl) carbamate

S-2,3-dichloroallyl N,N-diisopropylthiolcarbamate

S-ethyl-N,N-dipropylthiolcarbamate

S-propyl N,N-dipropylthiolcarbamate

S-2,3,3-trichloroallyl N,N-diisopropylthiolcarbamate

S-ethyl-N,N-diisobutylthiolcarbamate

Acetamides/Acetanilides/Anilines/Amides

2-Chloro-N,N-diallylacetamide

N,N-dimethyl-2,2-diphenylacetamide

N-(2,4-dimethyl-5-[[(trifluoromethyl)sulfonyl]amino]phenyl]acetamide N-Isopropyl-2-chloroacetanilide

2',6'-Diethyl-N-methoxymethyl-2-chloroacetanilide

2'-Methyl-6'-ethyl-N-(2-methoxyprop-2-yl)-2-chloroacetanilide

α,α,α-Trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine

N-(1,1-dimethylpropynyl)-3,5-dichlorobenzamide

Acids/Esters/Alcohols

2,2-Dichloropropionic acid

2-Methyl-4-chlorophenoxyacetic acid

2,4-Dichlorophenoxyacetic acid

Methyl-2-4-(2,4-dichlorophenoxy)phenoxy]propionate

3-Amino-2,5-dichlorobenzoic acid

2-Methoxy-3,6-dichlorobenzoic acid

2,3,6-Trichlorophenylacetic acid

N-1-naphthylphthalamic acid

Sodium 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate

4,6-Dinitro-o-sec-butylphenol

phenoxy]-propanoate

glyphosate

Ethers

2,4-Dichlorophenyl-4-nitrophenyl ether

2-Chloro-α,α,α-trifluoro-p-tolyl-3-ethoxy-4-nitrodiphenyl ether

5-(2-chloro-4-trifluoromethylphenoxy)-N-methylsulfonyl 2-nitrobenzamide

1'-(Carboethoxy) ethyl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate

Acifluorfen

Bifenox

Chloroxuron

Diclofop-methyl

Fluazifop-butyl

Miscellaneous

2,6-Dichlorobenzonitrile

Monosodium acid methanearsonate

Disodium methanearsonate

2-(2-chlorophenyl)methyl-4,4-dimethyl-3-isoxazolidinone

7-oxabicyclo (2.2.1) heptane, 1-methyl-4-(1-methyl ethyl)-2-(2-methylphenylmethoxy)-,exo- Sethoxydin

imazethapyr

imazaquin

imazapyr

Fertilizers useful in combination with the active ingredients include, for example ammonium nitrate, urea, potash and superphosphate. Other useful additaments include materials in which plant organisms take root and grow such as compost, manure, humus, sand and the like.

Herbicidal formulations of the types described above are exemplified in several illustrative embodiments below.

    ______________________________________                                                              Weight Percent                                            ______________________________________                                         I. Emulsifiable Concentrates                                                   A.    Compound of Example No. 1                                                                           11.0                                                      Free acid of complex organic                                                                        5.59                                                      phosphate or aromatic or                                                       aliphatic hydrophobe base                                                      (e.g., GAFAC RE-610, registered                                                trademark of GAF Corp.)                                                        Polyoxyethylene/polyoxypropylene                                                                    1.11                                                      block copolymer with butanol                                                   (e.g., Tergitol XH, registered                                                 trademark of Union Carbide Corp.)                                              Phenol               5.34                                                      Monochlorobenzene    76.96                                                                          100.00                                              B.    Compound of Example No. 1                                                                           25.00                                                     Free acid of complex organic                                                                        5.00                                                      phosphate of aromatic or                                                       aliphatic hydrophobe base                                                      (e.g., GAFAC RE-610)                                                           Polyoxyethylene/polyoxypropylene                                                                    1.60                                                      block copolymer with butanol                                                   (e.g., Tergitol XH)                                                            Phenol               4.75                                                      Monochlorobenzene    63.65                                                                          100.00                                              II. Flowables                                                                  A.    Compound of Example No. 1                                                                           25.00                                                     Methyl cellulose     0.3                                                       Silica Aerogel       1.5                                                       Sodium lignosulfonate                                                                               3.5                                                       Sodium N-methyl-N-oleyl taurate                                                                     2.0                                                       Water                67.7                                                                           100.00                                              B.    Compound of Example No. 1                                                                           45.0                                                      Methyl cellulose     .3                                                        Silica aerogel       1.5                                                       Sodium lignosulfonate                                                                               3.5                                                       Sodium N-methyl-N-oleyl taurate                                                                     2.0                                                       Water                 47.7                                                                          100.00                                              III. Wettable Powders                                                          A.    Compound of Example No. 1                                                                           25.0                                                      Sodium lignosulfonate                                                                               3.0                                                       Sodium N-methyl-N-oleyl-taurate                                                                     1.0                                                       Amorphous silica (synthetic)                                                                        71.0                                                                           100.00                                              B.    Compound of Example 1                                                                               80.00                                                     Sodium dioctyl sulfosuccinate                                                                       1.25                                                      Calcium lignosulfonate                                                                              2.75                                                      Amorphous silica (synthetic)                                                                        16.00                                                                          100.00                                              C.    Compound of Example No. 1                                                                           10.0                                                      Sodium lignosulfonate                                                                               3.0                                                       Sodium N-methyl-N-oleyl-taurate                                                                     1.0                                                       Kaolinite clay       86.0                                                                           100.00                                              IV. Dusts                                                                      A.    Compound of Example No. 1                                                                           2.0                                                       Attapulgite          98.0                                                                           100.00                                              B.    Compound of Example No. 1                                                                           30.0                                                      Ethylene glycol      1.0                                                       Bentonite            69.0                                                                           100.00                                              V. Granules                                                                    A.    Compound of Example No. 1                                                                           15.0                                                      Granular attapulgite (20/40 mesh)                                                                   85.0                                                                           100.00                                              B.    Compound of Example No. 1                                                                           30.0                                                      Diatomaceous earth (20/40)                                                                          70.0                                                                           100.00                                              C.    Compound of Example No. 1                                                                           1.0                                                       Ethylene glycol      5.0                                                       Methylene blue       0.1                                                       Pyrophyllite         93.9                                                                           100.00                                              ______________________________________                                    

When operating in accordance with the present invention, effective amounts of the compounds of this invention are applied to the soil containing the seeds, or vegetative propagules or may be incorporated into the soil media in any convenient fashion. The application of liquid and particulate solid compositions to the soil can be carried out by conventional methods, e.g., power dusters, boom and hand sprayers and spray dusters. The compositions can also be applied from airplanes as a dust or a spray because of their effectiveness at low dosages.

The exact amount of active ingredient to be employed is dependent upon various factors, including the plant species and stage of development thereof, the type and condition of soil, the amount of rainfall and the specific compounds employed. In selective pre-emergence application or to the soil, a dosage of from about 0.02 to about 11.2 kg/ha, preferably from about 0.1 to about 5.60 kg/ha, is usually employed. Lower or higher rates may be required in some instances. One skilled in the art can readily determine from this specification, including the above examples, the optimum rate to be applied in any particular case.

The term "soil" is employed in its broadest sense to be inclusive of all conventional "soils" as defined in Webster's New International Dictionary, Second Edition, Unabridged (1961). Thus, the term refers to any substance or medium in which vegetation may take root and grow, and includes not only earth but also compost, manure, muck, humus, loam, silt, mire, clay, sand, and the like, adapted to support plant growth.

Although the invention is described with respect to specific modifications, the details thereof are not to be construed as limitations, for it will be apparent that various embodiments, changes and modifications may be resorted to without departing from the spirit and scope thereof and it is understood that such equivalent embodiments are intended to be included within the scope of this invention. 

We claim:
 1. A 3-phenoxypyrazole or agronomically acceptable salt thereof wherein:the phenyl ring has a para nitro substituent; and the pyrazole ring has a methyl, ethyl, halomethyl or haloethyl substituent in the 1-position; a methyl substituent in the 4-position; and a chloro, cyano, halomethyl, haloethyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl or methoxymethyl substituent in the 5-position.
 2. The 3-phenoxypyrazole or salt of claim 1 wherein the pyrazole ring has a methyl substituent in the 1-position.
 3. The 3-phenoxypyrazole or salt of claim 2 wherein the pyrazole ring has a trifluoromethyl, a difluoromethyl or a methylsulfonyl substituent in the 5-position.
 4. A herbicidal composition comprising adjuvant and an effective amount of a 3-phenoxypyrazole or agronomically acceptable salt thereof wherein:the phenyl ring has a para nitro substituent; and the pyrazole ring has a methyl, ethyl, halomethyl or haloethyl substituent in the 1-position; a methyl substituent in the 4-position; and a chloro, cyano, halomethyl, haloethyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl or methoxymethyl substituent in the 5-position.
 5. The composition of claim 4 wherein the pyrazole ring has a methyl substituent in the 1-position.
 6. The composition of claim 5 wherein the pyrazole ring has a trifluoromethyl, a difluoromethyl or a methylsulfonyl substituent in the 5-position.
 7. A method of controlling the growth of undesirable vegetation comprising applying to the plant locus an effective amount of a 3-phenoxypyrazole or agronomically acceptable salt thereof wherein:the phenyl ring has a para nitro substituent; and the pyrazole ring has a methyl, ethyl, halomethyl or haloethyl substituent in the 1-position; a methyl substituent in the 4-position; and a chloro, cyano, halomethyl, haloethyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl or methoxymethyl substituent in the 5-position.
 8. The method of claim 7 wherein the pyrazole ring has a methyl substituent in the 1-position.
 9. The method of claim 8 wherein the pyrazole ring has a trifluoromethyl, a difluoromethyl or a methylsulfonyl substituent in the 5-position.
 10. A compound of the formula: ##STR47## wherein: R₁ is methyl or ethyl;R₂ is halomethyl, haloethyl, methylthio or ethylthio.
 11. A 3-phenoxypyrazole or agronomically acceptable salt thereof wherein:the phenyl ring has a para nitro substituent and a meta substituent having a molecular weight of less than about 300 and selected from alkoxy, haloalkoxy, di(alkoxy), alkoxycarbonyl, alkoxycarbonylalkoxy, aminocarbonylalkoxy, alkylsulfonylaminocarbonylalkoxy, alkylamino, hydroxyalkylamino, alkoxyamino, alkoxyalkylamino, hydroxycarbonylalkylamino, and alkoxycarbonylalkyloxyimino; and the pyrazole ring has a methyl substituent in the 1-position; a methyl substituent in the 4-position; and a chloro, cyano, halomethyl, haloethyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl, ethylsulfonyl or methoxymethyl substituent in the 5-position.
 12. The 3-phenoxypyrazole or salt of claim 11 wherein the pyrazole ring has a difluoromethyl, trifluoromethyl or methylsulfonyl substituent in the 5-position.
 13. A herbicidal composition comprising an adjuvant and an effective amount of a 3-phenoxypyrazole or agronimically acceptable salt thereof wherein:the phenyl ring has a para nitro substituent and a meta substituent having a molecular weight of less than about 300 and selected from alkoxy, haloalkoxy, di(alkoxy), alkoxycarbonyl, alkoxycarbonylalkoxy, aminocarbonylalkoxy, alkylsulfonylaminocarbonylalkoxy, alkylamino, hydroxyalkylamino, alkoxyamino, alkoxyalkylamino, hydroxycarbonylalkylamino, and alkoxycarbonylalkyloxyimino; and the pyrazole ring has a methyl substituent in the 1-position, a methyl substituent in the 4-position and a chloro, cyano, halomethyl, haloethyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, methylsulfonyl ethylsulfonyl or methoxymethyl substituent in the 5-position.
 14. The composition of claim 13 wherein the pyrazole ring has a difluoromethyl, trifluoromethyl or methylsulfonyl substituent in the 5-position.
 15. A method of controlling the growth of undesirable vegetation comprising applying to the plant locus an effective amount of a 3-phenoxypyrazole or agronomically acceptable salt thereof wherein:the phenyl ring has a para nitro substituent and a meta substituent having a molecular weight of less than about 300 and selected from alkoxy, haloalkoxy, di(alkoxy), alkoxycarbonyl, alkoxycarbonylalkoxy, aminocarbonylalkoxy, alkylsulfonylaminocarbonylalkoxy, alkylamino, hydroxyalkylamino, alkoxyamino, alkoxyalkylamino, hydroxycarbonylalkylamino, and alkoxycarbonylalkyloxyimino; and the pyrazole ring has a methyl substituent in the 1-position, a methyl substituent in the 4-position; and trifluoromethyl, a difluoromethyl or a methylsulfonyl substituent in the 5-position. 